Evidence map›Paper›PMID 33802355›Full record

ArticleJournal of personalized medicine2021

Drug Repurposing to Treat Glucocorticoid Resistance in Asthma.

Alberta L Wang, Ronald Panganiban, Weiliang Qiu, Alvin T Kho, Geoffrey Chupp, Deborah A Meyers, Eugene R Bleecker, Scott T Weiss, Quan Lu, Kelan G Tantisira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Pharmacogenetics of childhood uncontrolled asthma.Expert review of clinical immunology · 2025
    Review
  2. Article
  3. miRNAs as Modern Biomarkers in Asthma Therapy.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Carbocistein improves airway remodeling in asthmatic mice.American journal of translational research · 2022
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Alberta L WangChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Ronald PanganibanProgram in Molecular and Integrative Physiological Sciences, Departments of Environmental Health and Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-0894-1318
Weiliang QiuChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Alvin T KhoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Geoffrey ChuppDivision of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Deborah A MeyersDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Eugene R BleeckerDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Scott T WeissChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-7196-303X
Quan LuProgram in Molecular and Integrative Physiological Sciences, Departments of Environmental Health and Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Kelan G TantisiraDivision of Respiratory Medicine, Department of Pediatrics, University of California San Diego, San Diego, CA 92123, USA.
Brigham and Women's Hospital · USUniversity of Arizona · USUniversity of California San Diego · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6M
MICRORNAS AND EARLY LIFE EXPOSURES IN THE DEVELOPMENTAL ORIGIN OF ASTHMAR01HL125734 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SHARMA, SUNITA · 2016 to 2020
$3.5M
MICRORNAS IN CIRCULATION: ONTOLOGIES OF ASTHMA SEVERITY AND TREATMENT (MICROCOAST)R01HL127332 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2018
$3.4M
MicroRNA-10a in Airway Smooth Muscle and AsthmaR01HL139496 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI LU, QUAN · 2018 to 2021
$2.1M
DISEASE AND HEALTH: ASTHMA RESILIENCE THROUGH MICRORNA ATTRIBUTES (DHARMA)R01HL129935 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2017
$1.4M
Clinical prediction and epigenetic regulation of asthma and rhinitisK23HL151819 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, ALBERTA L. · 2021 to 2023
$639k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K23 HL151819NHLBI NIH HHS R01 HL139496NIAID NIH HHS L40 AI138248NIH HHS P01 HL132825NIH HHS R01 HL125734NIH HHS R01 HL127332NIH HHS R01 HL129935NIH HHS R01 HL139496NIH HHS R01 NR13391NIH HHS U01 HL65899Thrasher Research Fund 15115
6 · The paper itself

Abstract

Corticosteroid resistance causes significant morbidity in asthma, and drug repurposing may identify timely and cost-effective adjunctive treatments for corticosteroid resistance. In 95 subjects from the Childhood Asthma Management Program (CAMP) and 19 subjects from the Severe Asthma Research Program (SARP), corticosteroid response was measured by the change in percent predicted forced expiratory volume in one second (FEV

Indexed as

anti-asthmatic agentsasthmadrug repositioningglucocorticoid effect

Identifiers

PMID33802355
PMCPMC7999884
OpenAlexW3133658531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.