Evidence map›Paper›PMID 33802272›Full record

Trial reportInternational journal of environmental research and public health2021

A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Curcumin (

Emily K Donovan, Sophia Kekes-Szabo, Joanne C Lin, Rebecca L Massey, James D Cobb, Kathleen S Hodgin, Timothy J Ness, Carl Hangee-Bauer, Jarred W Younger

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05377242 (Curcumin, Resveratrol, and Stinging Nettle as Treatments for Gulf War Illness), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05377242 nacompletednot on this mapstarted 2023, after this paper: background citation

Curcumin, Resveratrol, and Stinging Nettle as Treatments for Gulf War Illness

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2023 to 2026Enrolled390ConditionsGulf War IllnessArmsCurcumin, Resveratrol, Stinging Nettle
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. PycnogenolFrontiers in nutrition · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Emily K DonovanDepartment of Psychology, Virginia Commonwealth University, White House, 806 West Franklin Street, Richmond, VA 23284, USA.ORCID 0000-0002-5246-6297
Sophia Kekes-SzaboDepartment of Psychology, Vanderbilt University, PMB 407817, 2301 Vanderbilt Place, Nashville, TN 37240, USA.ORCID 0000-0002-0603-3861
Joanne C LinSchool of Pharmacy, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand.
Rebecca L MasseyUAB School of Medicine, University of Alabama at Birmingham, 1670 University Blvd, Birmingham, AL 35223, USA.
James D CobbDepartment of Psychology, University of Alabama at Birmingham, CH 233, 1300 University Blvd, Birmingham, AL 35233, USA.
Kathleen S HodginDepartment of Psychology, University of Alabama at Birmingham, CH 233, 1300 University Blvd, Birmingham, AL 35233, USA.
Timothy J NessDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, BMR2-208, 901 19th St. S, Birmingham, AL 35205, USA.
Carl Hangee-BauerSan Francisco Natural Medicine, 1615 20th Street, San Francisco, CA 94107, USA.
Jarred W YoungerDepartment of Psychology, University of Alabama at Birmingham, CH 233, 1300 University Blvd, Birmingham, AL 35233, USA.
University of Alabama at Birmingham · USUniversity of Auckland · NZVanderbilt University · USVirginia Commonwealth University · US

Funding

National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
NCATS NIH HHS UL1 TR003096
6 · The paper itself

Abstract

This report is part of a larger study designed to rapidly and efficiently screen potential treatments for Gulf War Illness (GWI) by testing nine different botanicals. In this placebo-controlled, pseudo-randomized, crossover clinical trial of 20 men with GWI, we tested three botanical agents with putative peripheral and central anti-inflammatory actions: curcumin (

Indexed as

BoswelliaCurcuminPersian Gulf SyndromePinusCross-Over StudiesCurcumaGulf WarHumansMalePlant BarkPlant ExtractsCurcuminPlant Extractsboswelliacurcuminmaritime pine

Identifiers

PMID33802272
PMCPMC7967595
OpenAlexW3135253617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.