Evidence map›Paper›PMID 33802228›Full record

ArticleInternational journal of molecular sciences2021

The Anti-Melanogenesis Effect of 3,4-Dihydroxybenzalacetone through Downregulation of Melanosome Maturation and Transportation in B16F10 and Human Epidermal Melanocytes.

Yi-Jung Liu, Jia-Ling Lyu, Yueh-Hsiung Kuo, Chen-Yuan Chiu, Kuo-Chiang Wen, Hsiu-Mei Chiang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Bioactive Fractions Isolated fromCurrent drug research reviews · 2025
    Article
  3. Phenolic Glycoside Monomer fromCurrent medicinal chemistry · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Jelly Fig (Antioxidants (Basel, Switzerland) · 2022
    Article
  13. Protective Effect of Djulis (Molecules (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Aqueous extracts ofOncology letters · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi-Jung LiuPh.D. Program for Biotechnology Industry, China Medical University, Taichung 40402, Taiwan.
Jia-Ling LyuPh.D. Program for Biotechnology Industry, China Medical University, Taichung 40402, Taiwan.
Yueh-Hsiung KuoDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0001-5935-6755
Chen-Yuan ChiuCenter of Consultation, Center for Drug Evaluation (CDE), 3F, No.465, Sec.6, Zhongxiao E. Rd., Taipei 11557, Taiwan.ORCID 0000-0003-4378-993X
Kuo-Chiang WenDepartment of Cosmeceutics, China Medical University, Taichung 40402, Taiwan.
Hsiu-Mei ChiangPh.D. Program for Biotechnology Industry, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0002-1586-910X

Funding

China Medical University CMU107-BC-7 and CHM106-5-2the Ministry of Science and Technology MOST 106-2320-B-039-057-MY3
6 · The paper itself

Abstract

The biosynthesis pathway of melanin is a series of oxidative reactions that are catalyzed by melanin-related proteins, including tyrosinase (TYR), tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2). Reagents or materials with antioxidative or free radical-scavenging activities may be candidates for anti-melanogenesis. 3,4-Dihydroxybenzalacetone (DBL) is a polyphenol isolated from fungi, such as

Indexed as

Caffeic AcidsCell Line, TumorDown-RegulationEpidermisHumansMAP Kinase Signaling SystemMelanocytesMelanosomes3,4-dihydroxybenzalacetoneCaffeic Acids3,4-dihydroxybenzalacetonemelanogenesismelanosome maturationmelanosome transportmicrophthalmia-associated transcription factornatural antioxidantsPMEL17

Identifiers

PMID33802228
PMCPMC7999661

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.