Evidence map›Paper›PMID 33802224›Full record

ArticleBiomolecules2021

Medial Temporal Lobe Involvement in Human Prion Diseases: Implications for the Study of Focal Non Prion Neurodegenerative Pathology.

Alberto Rábano, Carmen Guerrero Márquez, Ramón A Juste, María V Geijo, Miguel Calero

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alberto RábanoNeuropathology Department, Alzheimer's Disease Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofía Foundation Alzheimer Research Center, 28031 Madrid, Spain.ORCID 0000-0001-9320-6566
Carmen Guerrero MárquezNeurological Tissue Bank-HUFA Biobank, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain.
Ramón A JusteDepartment of Animal Health, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Parque Científico y Tecnológico de Bizkaia P812, 48160 Derio, Spain.ORCID 0000-0001-6037-5873
María V GeijoDepartment of Animal Health, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Parque Científico y Tecnológico de Bizkaia P812, 48160 Derio, Spain.ORCID 0000-0002-3120-1038
Miguel CaleroCIEN Foundation and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Institute of Health Carlos III, 28031 Madrid, Spain.ORCID 0000-0001-5366-3324
Euskadiko Parke Teknologikoa · ESInstituto de Salud Carlos III · ESHospital Universitario Fundación Alcorcón · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human prion and non-prion neurodegenerative diseases share pathogenic mechanisms and neuropathological features. The lesion profile of a particular entity results from specific involvement of vulnerable neuron populations and connectivity circuits by a pathogenic protein isoform with strain-like properties. The lesion profile of the medial temporal lobe (MTL) was studied in postmortem tissue of 143 patients with human prion disease (HPD) including sporadic, genetic, and acquired forms. Most cases (90%) were classified according to PrP

Indexed as

AdultAgedFemaleHumansMaleMiddle AgedNerve DegenerationPrion DiseasesTemporal LobeVacuoleshuman prion diseasesmedial temporal lobeneurodegenerative diseasesprion strains

Identifiers

PMID33802224
PMCPMC7998497
OpenAlexW3135799126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.