ArticleAntioxidants (Basel, Switzerland)2021
Antioxidant and Antiglycation Effects of Polyphenol Compounds Extracted from Hazelnut Skin on Advanced Glycation End-Products (AGEs) Formation.
Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
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- Consensus In Silico Pharmacodynamic Screening of Twelve Fabaceae Isoflavones Targeting Glycation, Oxidative Stress, Antidiabetic Activity, and NF-κB-Related Inflammation.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The Algal Antioxidant Carotenoid Diatoxanthin as a Modulator of Inflammation and Angiogenesis in Triple-Negative Breast Cancer Cells.Antioxidants (Basel, Switzerland) · 2026Article
- Valorization of Hazelnut (Antioxidants (Basel, Switzerland) · 2025Article
- Synthetic and Natural Agents Targeting Advanced Glycation End-Products for Skin Anti-Aging: A Comprehensive Review of Experimental and Clinical Studies.Antioxidants (Basel, Switzerland) · 2025Review
- Inhibition mechanism of thermally induced furfural in simplified sugarcane juice model system by polyphenols.Food chemistry: X · 2025Article
- Effect of Extraction Methods on Chemical Characteristics and Bioactivity ofFoods (Basel, Switzerland) · 2024Article
- Changes in Phenolic Composition and Bioactivities of Ayocote Beans under Boiling (Molecules (Basel, Switzerland) · 2024Article
- Pistachio green hull and pomegranate peel extracts as two natural antiglycation agents.Food science & nutrition · 2024Article
- Protective effect ofHeliyon · 2024Article
- Study of the mechanism by gentiopicroside protects against skin fibroblast glycation damage via the RAGE pathway.Scientific reports · 2024Article
- Anti-Glycation Properties of Zinc-EnrichedNutrients · 2024Article
- Use of N-Methylmorpholine N-oxide (NMMO) pretreatment to enhance the bioconversion of lignocellulosic residues to methane.Biomass conversion and biorefinery · 2024Article
- Novel Fluorometric Assay of Antiglycation Activity Based on Methylglyoxal-Induced Protein Carbonylation.Antioxidants (Basel, Switzerland) · 2023Article
- Protective mechanism of fruit vinegar polyphenols against AGEs-induced Caco-2 cell damage.Food chemistry: X · 2023Article
- Skin health properties ofHeliyon · 2023Article
- Potential inhibitory effect of fish, maize, and whey protein hydrolysates on advanced glycation end-products (AGEs).Food science & nutrition · 2023Article
- Inhibition of oxidative stress and advanced glycation end-product formation in purified BSA/glucose glycation system by polyphenol extracts of selected nuts from Pakistan.Food science & nutrition · 2023Article
- Chemical Composition of Hazelnut Skin Food Waste and Protective Role against Advanced Glycation End-Products (AGEs) Damage in THP-1-Derived Macrophages.Molecules (Basel, Switzerland) · 2023Article
- Purification Process and In Vitro and In Vivo Bioactivity Evaluation of Pectolinarin and Linarin fromMolecules (Basel, Switzerland) · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The advanced glycation end-products (AGEs) arise from non-enzymatic reactions of sugar with protein side chains, some of which are oxido-reductive in nature. Enhanced production of AGEs plays an important role in the pathogenesis of diabetic complications as well as in natural aging, renal failure, oxidative stress, and chronic inflammation. The aim of this work is to study antiglycation effects of polyphenol compounds extracted by hazelnut skin that represents an example of polyphenols-rich food industry by-product, on AGEs formation. AGEs derived from incubation of bovine serum albumin (BSA) and methylglyoxal (MGO) were characterized by fluorescence. The phenolics identification and total polyphenol content in hazelnut skin extracts were analyzed by HPLC-MS and the Folin-Ciocalteu method, respectively. Antioxidant efficacy was evaluated by monitoring total antioxidant activity to assess the ABTS radical scavenging activity of samples by TEAC assay and oxygen radical absorbance capacity (ORAC) assay, expressed as millimoles of Trolox equivalents per gram of sample. Data here presented suggest that phenolic compounds in hazelnut skin have an inhibitory effect on the BSA-AGEs model in vitro, and this effect is concentration-dependent. The putative role of the hazelnut skin antioxidative properties for hindering AGEs formation is also discussed. Because of AGEs contribution to the pathogenesis of several chronic diseases, foods enriched, or supplements containing natural bioactive molecules able to inhibit their production could be an interesting new strategy for supporting therapeutic approaches with a positive effect on human health.
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