Evidence map›Paper›PMID 33802031›Full record

ArticleMolecules (Basel, Switzerland)2021

Solubility, Permeability, Anti-Inflammatory Action and In Vivo Pharmacokinetic Properties of Several Mechanochemically Obtained Pharmaceutical Solid Dispersions of Nimesulide.

Wei Wei, Veronica I Evseenko, Mikhail V Khvostov, Sergey A Borisov, Tatyana G Tolstikova, Nikolay E Polyakov, Aleksandr V Dushkin, Wenhao Xu, Lu Min, Weike Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Mechanochemical Transformations of Polysaccharides: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  2. Co-amorphization for solubility and dissolution rate improvement: the case of low-crystallization-tendency drugs.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wei WeiNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.ORCID 0000-0003-0862-8735
Veronica I EvseenkoInstitute of Solid State Chemistry and Mechanochemistry, Kutateladze, 18, Novosibirsk 630128, Russia.
Mikhail V KhvostovInstitute of Solid State Chemistry and Mechanochemistry, Kutateladze, 18, Novosibirsk 630128, Russia.ORCID 0000-0002-5906-4223
Sergey A BorisovN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev Avenue 9, Novosibirsk 630090, Russia.
Tatyana G TolstikovaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev Avenue 9, Novosibirsk 630090, Russia.
Nikolay E PolyakovInstitute of Solid State Chemistry and Mechanochemistry, Kutateladze, 18, Novosibirsk 630128, Russia.ORCID 0000-0002-3666-7750
Aleksandr V DushkinNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Wenhao XuNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Lu MinNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Weike SuNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.ORCID 0000-0003-2544-1948

Funding

Ministry of Science and Higher Education of the Russian Federation 0237-2021-0008Science and Technology Program of Zhejiang Province 2019C04023
6 · The paper itself

Abstract

Nimesulide (NIM,

Indexed as

2-Hydroxypropyl-beta-cyclodextrinAnimalsAnti-Inflammatory Agents, Non-Steroidalbeta-CyclodextrinsBiological AvailabilityCalorimetry, Differential ScanningChemistry, PharmaceuticalGalactansGlycyrrhizic AcidMagnesiumMaleMicePermeabilityPharmaceutical PreparationsSolubilitySulfonamides2-Hydroxypropyl-beta-cyclodextrinAnti-Inflammatory Agents, Non-Steroidalarabinogalactanbeta-CyclodextrinsGalactansGlycyrrhizic AcidMagnesiummagnesium carbonatenimesulidePharmaceutical PreparationsSulfonamidesanti-inflammatory actionbioavailabilitycomplexationdisodium salt of glycyrrhizic acidhydroxypropyl-β-cyclodextrinintrinsic solubilitymagnesium carbonatemicellesnimesulidepharmacokineticspolysaccharide arabinogalactansolid pharmaceutical dispersionssupramolecular complexes

Identifiers

PMID33802031
PMCPMC7998760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.