Evidence map›Paper›PMID 33802012›Full record

Trial reportNutrients2021

Urinary Titin N-Fragment Evaluation in a Randomized Controlled Trial of Beta-Hydroxy-Beta-Methylbutyrate for Acute Mild Trauma in Older Adults.

Hidehiko Nakano, Hideki Hashimoto, Masaki Mochizuki, Hiromu Naraba, Yuji Takahashi, Tomohiro Sonoo, Yujiro Matsuishi, Yasuhiro Ogawa, Nobutake Shimojo, Yoshiaki Inoue and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Observational
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hidehiko NakanoDepartment of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki 317-0077, Japan.ORCID 0000-0003-1384-634X
Hideki HashimotoDepartment of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki 317-0077, Japan.
Masaki MochizukiDepartment of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki 317-0077, Japan.
Hiromu NarabaDepartment of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki 317-0077, Japan.
Yuji TakahashiDepartment of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki 317-0077, Japan.
Tomohiro SonooDepartment of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki 317-0077, Japan.ORCID 0000-0002-9182-7059
Yujiro MatsuishiDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.ORCID 0000-0001-6388-9263
Yasuhiro OgawaDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Nobutake ShimojoDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Yoshiaki InoueDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Kensuke NakamuraDepartment of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki 317-0077, Japan.ORCID 0000-0001-8481-0294
Hitachi General Hospital · JPUniversity of Tsukuba · JP

Funding

General Insurance Association of Japan 19-1-060
6 · The paper itself

Abstract

The effects of beta-hydroxy-beta-methylbutyrate (HMB) complex administration and the significance of titin, a biomarker of muscle injury, in elderly minor trauma patients in acute phase has not been established. In this single-center, randomized controlled study, trauma patients aged ≥ 70 years with an injury severity score < 16 were included. Titin values on days 1 and 3 were measured and the intervention group received HMB complex (2.4 g of HMB + 14 g of glutamine + 14 g of arginine) and the control group received glutamine complex (7.2 g of protein including 6 g of glutamine). The cross-sectional area of the rectus femoris (RFCSA) on ultrasound, grip strength, and the Barthel Index were assessed on the first day of rehabilitation and after 2 weeks. We analyzed 24 HMB and 25 control participants. Titin values on day 3 correlated with grip strength (

Indexed as

Activities of Daily LivingAgedAged, 80 and overConnectinCreatinineDietary SupplementsFemaleHand StrengthHumansMaleMuscle, SkeletalPeptide FragmentsValeratesWounds and Injuriesbeta-hydroxyisovaleric acidConnectinCreatininePeptide FragmentsValeratesbeta-hydroxy-beta-methylbutyratefrailtymuscle injurysarcopeniatitin

Identifiers

PMID33802012
PMCPMC8001392
OpenAlexW3135559835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.