ArticlePolymers2021
Elucidating the Molecular Mechanisms for the Interaction of Water with Polyethylene Glycol-Based Hydrogels: Influence of Ionic Strength and Gel Network Structure.
Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Multi-Scale Water Modulation for Regulating Water Reactivity and Suppressing Nanoscale Zero-Valent Iron (nZVI) Corrosion.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Effects of Different Lignin Contents and Water Contents on the Performance of DES-Based Hydrogels.Gels (Basel, Switzerland) · 2026Article
- Tailoring Drug Release Profiles From Electrospun Alginate Fibers Through Integration of Mesoporous Silica Nanoparticles.Advanced healthcare materials · 2026Article
- Novel Superabsorbent Hydrogels Based on Polyacrylamide and White Angico Gum Enhanced with Kaolinitic Clay and Soapstone for Potential Agricultural Applications.International journal of molecular sciences · 2026Article
- Injectable Sodium Hyaluronate Hydrogels Modified by Ionic and Nonionic Polymers Loaded with Prednisolone Disodium Phosphate: Molecular Interactions and Intra-Articular Drug Delivery.International journal of molecular sciences · 2026Article
- Advances in Molecular Dynamics Simulations for Hydrogels and Nanocomposite-Reinforced Hydrogels: Multiscale Simulation Strategies and Future Directions.Gels (Basel, Switzerland) · 2026Review
- Impact of Water Conductivity on the Structure and Swelling Dynamics of E-Beam Cross-Linked Hydrogels.Gels (Basel, Switzerland) · 2025Article
- Enhancement of sandy soil water retention using superabsorbent carboxymethyl cellulose grafted with polyacrylamide and polyacrylamidomethyl propanesulfonic acid copolymer.Scientific reports · 2025Article
- A responsive living material prepared by diffusion reveals extracellular enzyme activity of cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Novel Buccal Xanthan Gum-Hyaluronic Acid Eutectogels with Dual Anti-Inflammatory and Antimicrobial Properties.Gels (Basel, Switzerland) · 2025Article
- Hydration Effects Driving Network Remodeling in Hydrogels during Cyclic Loading.ACS macro letters · 2025Article
- Crosslinking substrate regulates frictional properties of tissue-engineered cartilage and chondrocyte response to loading.Communications materials · 2025Article
- Design of PEG-Based Hydrogels as Soft Ionic Conductors.Journal of biomedical materials research. Part A · 2025Article
- Polyelectrolytes Are Effective Cryoprotectants for Extracellular Vesicles.ACS applied materials & interfaces · 2024Article
- In vivo biocompatibility assessment of 3D printed bioresorbable polymers for brain tissue regeneration. A feasibility study.Regenerative therapy · 2024Article
- Bioactive Polyurethane-Poly(ethylene Glycol) Diacrylate Hydrogels for Applications in Tissue Engineering.Gels (Basel, Switzerland) · 2024Article
- Preparation of PEG/P(U-AM-ChCl) composite hydrogels using ternary DES light polymerization and their properties.RSC advances · 2024Article
- Hydrocolloids of Egg White and Gelatin as a Platform for Hydrogel-Based Tissue Engineering.Gels (Basel, Switzerland) · 2023Article
- Water Diffusion and Uptake in Injectable ETTMP/PEGDA Hydrogels.The journal of physical chemistry. B · 2023Article
- State-of-the-Art Insights and Potential Applications of Cellulose-Based Hydrogels in Food Packaging: Advances towards Sustainable Trends.Gels (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The interaction of water within synthetic and natural hydrogel systems is of fundamental importance in biomaterial science. A systematic study is presented on the swelling behavior and states of water for a polyethylene glycol-diacrylate (PEGDA)-based model neutral hydrogel system that goes beyond previous studies reported in the literature. Hydrogels with different network structures are crosslinked and swollen in different combinations of water and phosphate-buffered saline (PBS). Network variables, polyethylene glycol (PEG) molecular weight (MW), and weight fraction are positively correlated with swelling ratio, while "non-freezable bound water" content decreases with PEG MW. The presence of ions has the greatest influence on equilibrium water and "freezable" and "non-freezable" water, with all hydrogel formulations showing a decreased swelling ratio and increased bound water as ionic strength increases. Similarly, the number of "non-freezable bound water" molecules, calculated from DSC data, is greatest-up to six molecules per PEG repeat unit-for gels swollen in PBS. Fundamentally, the balance of osmotic pressure and non-covalent bonding is a major factor within the molecular structure of the hydrogel system. The proposed model explains the dynamic interaction of water within hydrogels in an osmotic environment. This study will point toward a better understanding of the molecular nature of the water interface in hydrogels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.