Evidence map›Paper›PMID 33801773›Full record

ArticleCells2021

High Glucose Treatment Limits Drosha Protein Expression and Alters AngiomiR Maturation in Microvascular Primary Endothelial Cells via an Mdm2-dependent Mechanism.

Brian Lam, Emmanuel Nwadozi, Tara L Haas, Olivier Birot, Emilie Roudier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
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  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Brian LamMuscle Health Research Center, Angiogenesis Research Group, Faculty of Health, School of Kinesiology and Health Science, York University, Keele Street, Toronto, ON 4700, Canada.ORCID 0000-0001-9453-1520
Emmanuel NwadoziMuscle Health Research Center, Angiogenesis Research Group, Faculty of Health, School of Kinesiology and Health Science, York University, Keele Street, Toronto, ON 4700, Canada.ORCID 0000-0003-3572-9021
Tara L HaasMuscle Health Research Center, Angiogenesis Research Group, Faculty of Health, School of Kinesiology and Health Science, York University, Keele Street, Toronto, ON 4700, Canada.ORCID 0000-0001-8559-9574
Olivier BirotMuscle Health Research Center, Angiogenesis Research Group, Faculty of Health, School of Kinesiology and Health Science, York University, Keele Street, Toronto, ON 4700, Canada.ORCID 0000-0001-8430-2548
Emilie RoudierMuscle Health Research Center, Angiogenesis Research Group, Faculty of Health, School of Kinesiology and Health Science, York University, Keele Street, Toronto, ON 4700, Canada.
York University · CA

Funding

Natural Sciences and Engineering Research Council of Canada DGECR-2020-00133Natural Sciences and Engineering Research Council of Canada RGPIN-2017-05675Natural Sciences and Engineering Research Council of Canada RGPIN-2020-07142
6 · The paper itself

Abstract

Diabetes promotes an angiostatic phenotype in the microvascular endothelium of skeletal muscle and skin. Angiogenesis-related microRNAs (angiomiRs) regulate angiogenesis through the translational repression of pro- and anti-angiogenic genes. The maturation of micro-RNA (miRs), including angiomiRs, requires the action of DROSHA and DICER proteins. While hyperglycemia modifies the expression of angiomiRs, it is unknown whether high glucose conditions alter the maturation process of angiomiRs in dermal and skeletal muscle microvascular endothelial cells (MECs). Compared to 5 mM of glucose, high glucose condition (30 mM, 6-24 h) decreased DROSHA protein expression, without changing

Indexed as

AnimalsCells, CulturedEndothelial CellsGene Expression RegulationGlucoseHumansMaleMannitolMiceMice, Inbred C57BLMicroRNAsMicrovesselsNeovascularization, PhysiologicOsmotic PressureProtein BindingProto-Oncogene Proteins c-mdm2DROSHA protein, humanGlucoseMannitolMicroRNAsProto-Oncogene Proteins c-mdm2Ribonuclease IIIRNA, MessengerVascular Endothelial Growth Factor AangiogenesisangiostaticdermalDROSHAhyperglycemiaMDM2micro-RNA (miRs)microvascular endothelial cells (MECs)skeletal muscleVEGF-A

Identifiers

PMID33801773
PMCPMC8065922
OpenAlexW3152146330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.