Evidence map›Paper›PMID 33801772›Full record

ReviewViruses2021

Uniqueness of RNA Coliphage Qβ Display System in Directed Evolutionary Biotechnology.

Godwin W Nchinda, Nadia Al-Atoom, Mamie T Coats, Jacqueline M Cameron, Alain B Waffo

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Viral Genome Delivery Across Bacterial Cell Surfaces.Annual review of microbiology · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Godwin W NchindaLaboratory of Vaccinology and Biobanking, International Reference Centre CIRCB), BP 3077 Yaoundé, Cameroon.ORCID 0000-0003-0611-0561
Nadia Al-AtoomDepartment of Pathobiology, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA.
Mamie T CoatsClinical and Diagnostic Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jacqueline M CameronBiochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Alain B WaffoBiochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-0811-4649
Indiana University School of MedicineNnamdi Azikiwe University · NGTuskegee University · USUniversity of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phage display technology involves the surface genetic engineering of phages to expose desirable proteins or peptides whose gene sequences are packaged within phage genomes, thereby rendering direct linkage between genotype with phenotype feasible. This has resulted in phage display systems becoming invaluable components of directed evolutionary biotechnology. The M13 is a DNA phage display system which dominates this technology and usually involves selected proteins or peptides being displayed through surface engineering of its minor coat proteins. The displayed protein or peptide's functionality is often highly reduced due to harsh treatment of M13 variants. Recently, we developed a novel phage display system using the coliphage Qβ as a nano-biotechnology platform. The coliphage Qβ is an RNA phage belonging to the family of

Indexed as

BiotechnologyCell Surface Display TechniquesColiphagesDirected Molecular EvolutionQuasispeciesRNA, ViralRNA, ViralA1A2affinity maturationevolutionary biotechnologyfitness landscapeF+, minor coaticosahedronin vitro evolutionLeviviridaeM13major coatpIIIquasispeciesQβreplicasetryptophanUGA

Identifiers

PMID33801772
PMCPMC8067240
OpenAlexW3150103086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.