Evidence map›Paper›PMID 33801762›Full record

ArticleInternational journal of molecular sciences2021

Investigation of the Interaction of Human Origin Recognition Complex Subunit 1 with G-Quadruplex DNAs of Human

Afaf Eladl, Yudai Yamaoki, Shoko Hoshina, Haruka Horinouchi, Keiko Kondo, Shou Waga, Takashi Nagata, Masato Katahira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Biophysical Study of the Structure, Dynamics, and Function of Nucleic Acids.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Afaf EladlInstitute of Advanced Energy, Kyoto University, Kyoto 611-0011, Japan.
Yudai YamaokiInstitute of Advanced Energy, Kyoto University, Kyoto 611-0011, Japan.ORCID 0000-0002-8927-4985
Shoko HoshinaDepartment of Chemical and Biological Sciences, Japan Women's University, Tokyo 112-8681, Japan.
Haruka HorinouchiDepartment of Chemical and Biological Sciences, Japan Women's University, Tokyo 112-8681, Japan.
Keiko KondoInstitute of Advanced Energy, Kyoto University, Kyoto 611-0011, Japan.ORCID 0000-0003-2860-2751
Shou WagaDepartment of Chemical and Biological Sciences, Japan Women's University, Tokyo 112-8681, Japan.ORCID 0000-0003-4986-8735
Takashi NagataInstitute of Advanced Energy, Kyoto University, Kyoto 611-0011, Japan.ORCID 0000-0002-3733-2709
Masato KatahiraInstitute of Advanced Energy, Kyoto University, Kyoto 611-0011, Japan.
Kyoto University · JPJapan Women's University · JPZagazig University · EG

Funding

Ministry of Education, Culture, Sports, Science and Technology 19K16054Ministry of Education, Culture, Sports, Science and Technology 20H03192Ministry of Education, Culture, Sports, Science and Technology 20K06524Ministry of Education, Culture, Sports, Science and Technology 20K21477The Joint Usage/Joint Research Center for Zero Emission Energy Research, Institute of Advanced Energy, Kyoto University ZE2020A-39
6 · The paper itself

Abstract

Origin recognition complex (ORC) binds to replication origins in eukaryotic DNAs and plays an important role in replication. Although yeast ORC is known to sequence-specifically bind to a replication origin, how human ORC recognizes a replication origin remains unknown. Previous genome-wide studies revealed that guanine (G)-rich sequences, potentially forming G-quadruplex (G4) structures, are present in most replication origins in human cells. We previously suggested that the region comprising residues 413-511 of human ORC subunit 1, hORC1

Indexed as

G-QuadruplexesOrigin Recognition ComplexPromoter Regions, GeneticBinding SitesDNADNA ReplicationFluorescence PolarizationHumansMagnetic Resonance SpectroscopyOpen Reading FramesProtein BindingProto-Oncogene Proteins c-mycReplication OriginTelomereDNAMYC protein, humanORC1 protein, humanOrigin Recognition ComplexProto-Oncogene Proteins c-mycDNA replicationG-quadruplexNMRorigin recognition complexreplication originstructure

Identifiers

PMID33801762
PMCPMC8036949
OpenAlexW3145354371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.