Evidence map›Paper›PMID 33801752›Full record

ArticleInternational journal of molecular sciences2021

Bio-Engineered Nisin with Increased Anti-

Des Field, Kiera Considine, Paula M O'Connor, R Paul Ross, Colin Hill, Paul D Cotter

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

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  16. Nisin S, a Novel Nisin Variant Produced byInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Des FieldSchool of Microbiology, University College Cork, T12 K8AF Cork, Ireland.ORCID 0000-0003-4425-5817
Kiera ConsidineTeagasc Food Research Centre, Moorepark, Fermoy, Co., P61 C996 Cork, Ireland.
Paula M O'ConnorTeagasc Food Research Centre, Moorepark, Fermoy, Co., P61 C996 Cork, Ireland.
R Paul RossSchool of Microbiology, University College Cork, T12 K8AF Cork, Ireland.
Colin HillSchool of Microbiology, University College Cork, T12 K8AF Cork, Ireland.ORCID 0000-0002-8527-1445
Paul D CotterAPC Microbiome Ireland, T12 YT20 Cork, Ireland.
Teagasc - The Irish Agriculture and Food Development Authority · IEUniversity College Cork · IE

Funding

Science Foundation Ireland SFI/12/RC/2273 P2; SFI/11/PI/1137; SFI14/TIDA/2286.
6 · The paper itself

Abstract

Bovine mastitis is a significant economic burden for dairy enterprises, responsible for premature culling, prophylactic and therapeutic antibiotic use, reduced milk production and the withholding (and thus wastage) of milk. There is a desire to identify novel antimicrobials that are expressly directed to veterinary applications, do not require a lengthy milk withholding period and that will not have a negative impact on the growth of lactic acid bacteria involved in downstream dairy fermentations. Nisin is the prototypical lantibiotic, a family of highly modified antimicrobial peptides that exhibit potent antimicrobial activity against many Gram-positive microbes, including human and animal pathogens including species of

Indexed as

AnimalsAnti-Bacterial AgentsBacteriocinsBioengineeringCattleFemaleLactococcusMastitis, BovineMicrobial Sensitivity TestsMilkNisinPeptidesProtein EngineeringStaphylococcusAnti-Bacterial AgentsBacteriocinsNisinnisin APeptidesantimicrobialbacteriocinbovine mastitislantibioticnisinpeptide engineeringS. aureusstaphylococci

Identifiers

PMID33801752
PMCPMC8036683
OpenAlexW3149886199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.