Evidence map›Paper›PMID 33801382›Full record

ArticleCancers2021

In Vivo Biodistribution and Efficacy Evaluation of NeoB, a Radiotracer Targeted to GRPR, in Mice Bearing Gastrointestinal Stromal Tumor.

Christopher Montemagno, Florian Raes, Mitra Ahmadi, Sandrine Bacot, Marlène Debiossat, Julien Leenhardt, Jean Boutonnat, Francesca Orlandi, Donato Barbato, Mattia Tedesco and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Phase 1 Study of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Trial
  2. RM2 and DB15 analogues bearing [EJNMMI radiopharmacy and chemistry · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Advances in Radioligand Theranostics in Oncology.Molecular diagnosis & therapy · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Safety of [European journal of nuclear medicine and molecular imaging · 2022
    Article
  14. Article
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Christopher MontemagnoLaboratoire radiopharmaceutiques biocliniques (LRB), Universite Grenoble Alpes, Inserm, CHU Grenoble Alpes, LRB, 38000 Grenoble, France.ORCID 0000-0002-5687-1812
Florian RaesLaboratoire radiopharmaceutiques biocliniques (LRB), Universite Grenoble Alpes, Inserm, CHU Grenoble Alpes, LRB, 38000 Grenoble, France.
Mitra AhmadiLaboratoire radiopharmaceutiques biocliniques (LRB), Universite Grenoble Alpes, Inserm, CHU Grenoble Alpes, LRB, 38000 Grenoble, France.
Sandrine BacotLaboratoire radiopharmaceutiques biocliniques (LRB), Universite Grenoble Alpes, Inserm, CHU Grenoble Alpes, LRB, 38000 Grenoble, France.
Marlène DebiossatLaboratoire radiopharmaceutiques biocliniques (LRB), Universite Grenoble Alpes, Inserm, CHU Grenoble Alpes, LRB, 38000 Grenoble, France.
Julien LeenhardtLaboratoire radiopharmaceutiques biocliniques (LRB), Universite Grenoble Alpes, Inserm, CHU Grenoble Alpes, LRB, 38000 Grenoble, France.ORCID 0000-0002-2863-5011
Jean BoutonnatTherex, Universite Grenoble Alpes, CNRS, CHU Grenoble Alpes, Therex, 38000 Grenoble, France.
Francesca OrlandiAdvanced Accelerator Applications, a Novartis Company, 10010 Colleretto Giacosa (TO), Italy.
Donato BarbatoAdvanced Accelerator Applications, a Novartis Company, 10010 Colleretto Giacosa (TO), Italy.
Mattia TedescoAdvanced Accelerator Applications, a Novartis Company, 10010 Colleretto Giacosa (TO), Italy.
Catherine GhezziLaboratoire radiopharmaceutiques biocliniques (LRB), Universite Grenoble Alpes, Inserm, CHU Grenoble Alpes, LRB, 38000 Grenoble, France.
Pascale PerretLaboratoire radiopharmaceutiques biocliniques (LRB), Universite Grenoble Alpes, Inserm, CHU Grenoble Alpes, LRB, 38000 Grenoble, France.
Alexis BroisatLaboratoire radiopharmaceutiques biocliniques (LRB), Universite Grenoble Alpes, Inserm, CHU Grenoble Alpes, LRB, 38000 Grenoble, France.ORCID 0000-0002-4265-8463
Inserm · FRNovartis (Italy) · ITCentre National de la Recherche Scientifique · FR

Funding

Agence Nationale de la Recherche ANR-11-INBS-0006FP7 Health 602306
6 · The paper itself

Abstract

NeoB is a radiotracer targeting the gastrin-releasing peptide receptor (GRPR), a G-protein-coupled receptor expressed in various cancers. The aim of the present study was to evaluate the biodistribution and efficacy of this new therapeutic agent in Gastrointestinal Stromal Tumors (GIST). Eighty-two SCID mice bearing GIST-882 tumors were employed. [

Indexed as

[177Lu]Lu-NeoBgastrin releasing peptide receptorGIST tumorNeoBOMB1theragnostictheranostic

Identifiers

PMID33801382
PMCPMC7958597
OpenAlexW3134374337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.