Evidence map›Paper›PMID 33801371›Full record

ArticleMolecules (Basel, Switzerland)2021

Coumarin-Annulated Ferrocenyl 1,3-Oxazine Derivatives Possessing In Vitro Antimalarial and Antitrypanosomal Potency.

Mziyanda Mbaba, Laura M K Dingle, Ayanda I Zulu, Dustin Laming, Tarryn Swart, Jo-Anne de la Mare, Heinrich C Hoppe, Adrienne L Edkins, Setshaba D Khanye

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mziyanda MbabaDepartment of Chemistry, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0002-1608-6801
Laura M K DingleDepartment of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0002-3041-2861
Ayanda I ZuluDepartment of Chemistry, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0001-9036-5588
Dustin LamingDepartment of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0003-2734-0999
Tarryn SwartDepartment of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.
Jo-Anne de la MareDepartment of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.
Heinrich C HoppeDepartment of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0003-4409-1955
Adrienne L EdkinsDepartment of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0002-3615-6651
Setshaba D KhanyeDepartment of Chemistry, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0003-0725-5738

Funding

National Research Foundation 107270 (S.D.K.); 190403426633 (J.DLM.)National Research Foundation CPRR 105829 (A.L.E.)The South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation of South Africa 98566 (A.L.E.)
6 · The paper itself

Abstract

A tailored series of coumarin-based ferrocenyl 1,3-oxazine hybrid compounds was synthesized and investigated for potential antiparasitic activity, drawing inspiration from the established biological efficacy of the constituent chemical motifs. The structural identity of the synthesized compounds was confirmed by common spectroscopic techniques: NMR, HRMS and IR. Biological evaluation studies reveal that the compounds exhibit higher in vitro antiparasitic potency against the chemosensitive malarial strain (3D7

Indexed as

AntimalarialsAntiprotozoal AgentsCell ProliferationCell SurvivalCoumarinsFemaleFerrous CompoundsHumansIn Vitro TechniquesMolecular StructureOxazinesPlasmodium falciparumStructure-Activity RelationshipTriple Negative Breast NeoplasmsTrypanosoma brucei bruceiTumor Cells, CulturedAntimalarialsAntiprotozoal AgentscoumarinCoumarinsFerrous CompoundsOxazinesbioorganometalliccancercoumarinferrocenemalariamode of actionorganometallicoxazinePlasmodium falciparumTrypanosoma bruceitrypanosomiasis

Identifiers

PMID33801371
PMCPMC7958634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.