Evidence map›Paper›PMID 33801334›Full record

ReviewCancers2021

The Role of Network Science in Glioblastoma.

Marta B Lopes, Eduarda P Martins, Susana Vinga, Bruno M Costa

Abstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Brain tumour genetic network signatures of survival.Brain : a journal of neurology · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marta B LopesCenter for Mathematics and Applications (CMA), FCT, UNL, 2829-516 Caparica, Portugal.ORCID 0000-0002-4135-1857
Eduarda P MartinsLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0002-4248-7457
Susana VingaINESC-ID, Instituto Superior Técnico, Universidade de Lisboa, 1000-029 Lisbon, Portugal.ORCID 0000-0002-1954-5487
Bruno M CostaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0003-4861-7432

Funding

Fundação para a Ciência e a Tecnologia CEECIND/00072/2018Fundação para a Ciência e a Tecnologia CEECINST/00102/2018Fundação para a Ciência e a Tecnologia DSAIPA/DS/0026/2019Fundação para a Ciência e a Tecnologia PD/BDE/143154/2019Fundação para a Ciência e a Tecnologia PTDC/CCI-BIO/4180/2020Horizon 2020 951970
6 · The paper itself

Abstract

Network science has long been recognized as a well-established discipline across many biological domains. In the particular case of cancer genomics, network discovery is challenged by the multitude of available high-dimensional heterogeneous views of data. Glioblastoma (GBM) is an example of such a complex and heterogeneous disease that can be tackled by network science. Identifying the architecture of molecular GBM networks is essential to understanding the information flow and better informing drug development and pre-clinical studies. Here, we review network-based strategies that have been used in the study of GBM, along with the available software implementations for reproducibility and further testing on newly coming datasets. Promising results have been obtained from both bulk and single-cell GBM data, placing network discovery at the forefront of developing a molecularly-informed-based personalized medicine.

Indexed as

biomarker selectioncausal discoverydifferential network expressionmodel regularizationmulti-omicsnetwork analysispersonalized therapyprecision medicine

Identifiers

PMID33801334
PMCPMC7958335

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.