Evidence map›Paper›PMID 33801155›Full record

ReviewInternational journal of molecular sciences2021

Immunoglobulins and Transcription Factors in Otitis Media.

Su Young Jung, Dokyoung Kim, Dong Choon Park, Eun Hye Lee, Yong-Sung Choi, Jeewon Ryu, Sang Hoon Kim, Seung Geun Yeo

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. IgM mediated cefotaxime resistance ofAmerican journal of translational research · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. [Clinical features, diagnosis and treatment for patients presenting with granulation tissue of the external auditory canal].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022
    Article
  10. Article
  11. Toll-Like Receptors: Expression and Roles in Otitis Media.International journal of molecular sciences · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Su Young JungDepartment of Otorhinolaryngology-Head and Neck Surgery, Myongji Hospital, Hanyang University College of Medicine, Goyang 10475, Korea.ORCID 0000-0001-6398-1297
Dokyoung KimDepartment of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0002-7756-3560
Dong Choon ParkDepartment of Gynecologic Oncology, St. Vincent's Hospital, The Catholic University of Korea, Suwon 16247, Korea.
Eun Hye LeeDepartment of Pediatrics, College of Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Yong-Sung ChoiDepartment of Pediatrics, College of Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Jeewon RyuDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0001-5928-5272
Sang Hoon KimDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
Seung Geun YeoDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0001-8021-1024
Kyung Hee University · KRMyongji Hospital · KRThe Catholic University of Korea St. Vincent's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The causes of otitis media (OM) involve bacterial and viral infection, anatomo-physiological abnormalities of the Eustachian canal and nasopharynx, allergic rhinitis, group childcare centers, second-hand smoking, obesity, immaturity and defects of the immune system, formula feeding, sex, race, and age. OM is accompanied by complex and diverse interactions among bacteria, viruses, inflammatory cells, immune cells, and epithelial cells. The present study summarizes the antibodies that contribute to immune reactions in all types of otitis media, including acute otitis media, otitis media with effusion, and chronic otitis media with or without cholesteatoma, as well as the transcription factors that induce the production of these antibodies. The types and distribution of B cells; the functions of B cells, especially in otorhinolaryngology; antibody formation in patients with otitis media; and antibodies and related transcription factors are described. B cells have important functions in host defenses, including antigen recognition, antigen presentation, antibody production, and immunomodulation. The phenotypes of B cells in the ear, nose, and throat, especially in patients with otitis media, were shown to be CD5

Indexed as

Disease SusceptibilityAnimalsAntibody FormationB-Lymphocyte SubsetsDisease ManagementGene Expression RegulationHumansImmunoglobulin AImmunoglobulinsOtitis MediaTranscription FactorsImmunoglobulin AImmunoglobulinsTranscription Factorsacute otitis mediaantibodychronic otitis mediaimmunoglobulinotitis mediaotitis media with effusion

Identifiers

PMID33801155
PMCPMC8004237
OpenAlexW3137171300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.