Evidence map›Paper›PMID 33801154›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Addressing Pediatric HIV Pretreatment Drug Resistance and Virologic Failure in Sub-Saharan Africa: A Cost-Effectiveness Analysis of Diagnostic-Based Strategies in Children ≥3 Years Old.

Mutita Siriruchatanon, Shan Liu, James G Carlucci, Eva A Enns, Horacio A Duarte

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mutita SiriruchatanonDepartment of Industrial & Systems Engineering, University of Washington, Seattle, WA 98185, USA.
Shan LiuDepartment of Industrial & Systems Engineering, University of Washington, Seattle, WA 98185, USA.ORCID 0000-0003-1459-8923
James G CarlucciDepartment of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-3969-8544
Eva A EnnsDivision of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, MN 55408, USA.ORCID 0000-0003-0693-7358
Horacio A DuarteDepartment of Pediatrics, Division of Infectious Diseases, University of Washington, Seattle, WA 98105, USA.
University of Washington · USIndiana University School of MedicineUniversity of Minnesota · US

Funding

VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
Center for AIDS Research, University of Washington AI027757Gilead Sciences HIV Research Scholars ProgramNIAID NIH HHS T32 AI007140Pharmaceutical Research and Manufacturers of America Foundation Health Outcomes Research Starter Grant
6 · The paper itself

Abstract

Improvement of antiretroviral therapy (ART) regimen switching practices and implementation of pretreatment drug resistance (PDR) testing are two potential approaches to improve health outcomes for children living with HIV. We developed a microsimulation model of disease progression and treatment focused on children with perinatally acquired HIV in sub-Saharan Africa who initiate ART at 3 years of age. We evaluated the cost-effectiveness of diagnostic-based strategies (

Indexed as

Africadolutegravir-based ARTdrug resistance testingHIVNNRTI-based ARTpretreatment drug resistanceregimen switchingvirologic failure

Identifiers

PMID33801154
PMCPMC8004076
OpenAlexW3136049142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.