Evidence map›Paper›PMID 33801151›Full record

ArticleMolecules (Basel, Switzerland)2021

Identification of Potential SARS-CoV-2 Main Protease and Spike Protein Inhibitors from the Genus

Mohamed E Abouelela, Hamdy K Assaf, Reda A Abdelhamid, Ehab S Elkhyat, Ahmed M Sayed, Tomasz Oszako, Lassaad Belbahri, Ahmed E El Zowalaty, Mohamed Salaheldin A Abdelkader

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 38 citations in OpenAlex.

  1. In Silico Screening ofBiologics : targets & therapy · 2025
    Article
  2. Foods (Basel, Switzerland) · 2024
    Review
  3. Identification of PotentialMetabolites · 2023
    Article
  4. Review
  5. Article
  6. A Comprehensive In Silico Study of New Metabolites fromMolecules (Basel, Switzerland) · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Chemical constituents fromRSC advances · 2022
    Article
  11. Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Review
  12. Article
  13. Article
  14. RSC advances · 2021
    Article
  15. Molecules (Basel, Switzerland) · 2021
    Article
  16. SARS-CoV-2: Emergence of New Variants and Effectiveness of Vaccines.Frontiers in cellular and infection microbiology · 2021
    Review
  17. Review on the phytochemistry and toxicological profiles ofFuture journal of pharmaceutical sciences · 2021
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Mohamed E AbouelelaDepartment of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut 71524, Egypt.ORCID 0000-0002-9489-234X
Hamdy K AssafDepartment of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut 71524, Egypt.ORCID 0000-0002-9845-0020
Reda A AbdelhamidDepartment of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut 71524, Egypt.
Ehab S ElkhyatDepartment of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut 71524, Egypt.
Ahmed M SayedDepartment of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt.ORCID 0000-0002-1442-183X
Tomasz OszakoDepartment of Forest Protection, Forest Research Institute, 05-090 Sekocin Stary, Poland.ORCID 0000-0003-4688-2582
Lassaad BelbahriLaboratory of Soil Biology, University of Neuchatel, 2000 Neuchatel, Switzerland.ORCID 0000-0001-7040-4500
Ahmed E El ZowalatySahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0000-0001-6177-6142
Mohamed Salaheldin A AbdelkaderDepartment of Pharmacognosy, Faculty of Pharmacy, Sohag University, Nasr City, Sohag 82524, Egypt.
Al-Azhar University · EGInstytut Badawczy Leśnictwa · PLNahda University · EGSohag University · EGUniversity of Gothenburg · SEUniversity of Neuchâtel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) disease is a global rapidly spreading virus showing very high rates of complications and mortality. Till now, there is no effective specific treatment for the disease.

Indexed as

Drug DevelopmentAloeAntiviral AgentsComputational BiologyCoronavirus 3C ProteasesCOVID-19 Drug TreatmentDrug DiscoveryMolecular Docking SimulationMolecular Dynamics SimulationPhytochemicalsProtein BindingSARS-CoV-2Spike Glycoprotein, CoronavirusThermodynamics3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesPhytochemicalsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2AloeCOVID-19dockingmain proteaseMD simulationSARS-CoV-2spike glycoprotein

Identifiers

PMID33801151
PMCPMC8004122
OpenAlexW3136293805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.