ArticleJournal of clinical medicine2021
Longitudinal Femoral Cartilage T2 Relaxation Time and Thickness Changes with Fast Sequential Radiographic Progression of Medial Knee Osteoarthritis-Data from the Osteoarthritis Initiative (OAI).
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06267053 (Investigation of the Relationship Between Vitamin B12, Folic Acid and 25 OH D Levels and Radiologic Stage in Knee Osteoarthritis), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Relationship Between Vitamin B12, Folic Acid and 25 OH D Levels and Radiologic Stage in Knee Osteoarthritis
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Defining and predicting radiographic knee osteoarthritis progression: a systematic review of findings from the osteoarthritis initiative.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Pooled it
- Evaluation of Pre-Operative Cartilage and Meniscus Ultrashort Echo Time T2* as Biomarkers of Long-Term Clinical Outcomes Following Anterior Cruciate Ligament Reconstruction.Journal of magnetic resonance imaging : JMRI · 2026Article
- Exploratory analysis of the 2-year changes in knee cartilage thickness and transverse relaxation time (T2) in ACL-injured versus healthy participants.Osteoarthritis and cartilage open · 2026Article
- Association between constant and intermittent knee pain and T2 values and cartilage thickness: data from the osteoarthritis initiative.Arthritis research & therapy · 2025Article
- TJournal of magnetic resonance imaging : JMRI · 2025Article
- Improving Accuracy and Reproducibility of Cartilage TJournal of magnetic resonance imaging : JMRI · 2025Article
- Standardized maps - an emerging approach to leverage quantitative information in knee imaging.Osteoarthritis imaging · 2024Article
- Associations of Longitudinal Multiparametric MRI Findings and Clinical Outcomes in Intra-Articular Injections for Knee Osteoarthritis.Diagnostics (Basel, Switzerland) · 2024Article
- Clinical and imaging findings associated with preservation of knee joint health over 8 years in individuals aged 65 and over: data from the OAI.BMC musculoskeletal disorders · 2024Article
- Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study tested for longitudinal changes in femoral cartilage T2 relaxation time and thickness in fast-progressing medial femorotibial osteoarthritis (OA). From the Osteoarthritis Initiative (OAI) database, nineteen knees fulfilled the inclusion criteria, which included medial femorotibial OA and sequential progression from Kellgren-Lawrence grade (KL) 1 to KL2 to KL3 within five years. Median T2 value and mean thickness were calculated for six condylar volumes of interest (VOIs; medial/lateral anterior, central, posterior) and six sub-VOIs (medial/lateral anterior external, central, internal). T2 value and thickness changes between severity timepoints were tested using repeated statistics. T2 values increased between KL1 and KL2 and between KL1 and KL3 in the medial compartment (
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