Evidence map›Paper›PMID 33800989›Full record

ArticleCells2021

Endometriosis Is Associated with Functional Polymorphism in the Promoter of Heme Oxygenase 1 (

Łukasz Milewski, Aneta Ścieżyńska, Joanna Ponińska, Marta Soszyńska, Ewa Barcz, Piotr I Roszkowski, Paweł Kamiński, Paweł Włodarski, Rafał Płoski, Jacek Malejczyk

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Łukasz MilewskiDepartment of Histology and Embryology, Centre for Biostructure Research, Medical University of Warsaw, 02-004 Warsaw, Poland.
Aneta ŚcieżyńskaDepartment of Histology and Embryology, Centre for Biostructure Research, Medical University of Warsaw, 02-004 Warsaw, Poland.
Joanna PonińskaDepartment of Medical Biology, National Institute of Cardiology, 04-628 Warsaw, Poland.
Marta SoszyńskaDepartment of Histology and Embryology, Centre for Biostructure Research, Medical University of Warsaw, 02-004 Warsaw, Poland.
Ewa Barcz1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland.
Piotr I Roszkowski2nd Department of Obstetrics and Gynecology, Medical University of Warsaw, 00-315 Warsaw, Poland.
Paweł KamińskiDepartment of Gynecology and Gynecological Oncology, Military Institute of Medicine, 04-349 Warsaw, Poland.
Paweł WłodarskiDepartment of Methodology, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0002-0683-1791
Rafał PłoskiDepartment of Medical Genetics, Centre for Biostructure Research, Medical University of Warsaw, 02-106 Warsaw, Poland.ORCID 0000-0001-6286-5526
Jacek MalejczykDepartment of Histology and Embryology, Centre for Biostructure Research, Medical University of Warsaw, 02-004 Warsaw, Poland.ORCID 0000-0002-5371-8476
Medical University of Warsaw · PLInstitute of Cardiology · PLWojskowy Instytut Medycyny Lotniczej · PL

Funding

Warszawski Uniwersytet Medyczny 1M15/N/10Warszawski Uniwersytet Medyczny 1M15/NK1W/09
6 · The paper itself

Abstract

Endometriosis is a common gynecological disorder characterized by the ectopic growth of endometrial-like tissue outside the uterine cavity. Etiopathogenesis of endometriosis is poorly understood; it is plausible, however, that the disease may be associated with oxidative stress related to local heme and iron metabolism. Therefore, the aim of the study was to reveal a possible association of endometriosis with a stress-inducible heme oxygenase 1 (HMOX1). For this purpose, 228 patients with clinically confirmed endometriosis and 415 control parous women from general Polish population were examined for functional -413A>T (rs2071746) single-nucleotide polymorphism (SNP) and (

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseasePromoter Regions, GeneticAdultCase-Control StudiesEndometriosisFemaleGene FrequencyHaplotypesHeme Oxygenase-1HumansMiddle AgedPolymorphism, Single NucleotideYoung AdultHeme Oxygenase-1HMOX1 protein, humanendometriosisheme oxygenase 1inflammatory responsesingle-nucleotide polymorphism

Identifiers

PMID33800989
PMCPMC8003868
OpenAlexW3138684837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.