Evidence map›Paper›PMID 3380093›Full record

ArticleMolecular and cellular biology1988

Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.

C J Thiele, P S Cohen, M A Israel

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
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  9. myb provides an essential function during Drosophila development.Proceedings of the National Academy of Sciences of the United States of America · 1996
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  14. A human Id-like helix-loop-helix protein expressed during early development.Proceedings of the National Academy of Sciences of the United States of America · 1992
    Article
  15. Article
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  19. trans activation of gene expression by v-myb.Molecular and cellular biology · 1990
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

C J ThieleMolecular Genetics Section, National Cancer Institute, Bethesda, Maryland 20892.
P S Cohen
M A Israel
National Cancer Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We detected expression of the c-myb proto-oncogene, which was initially thought to be expressed in a tissue-specific manner in cells of hematopoietic lineage, in human tissues of neuronal origin. Since the level of c-myb expression declined during fetal development, we studied the regulation of its expression in human neuroblastoma cell lines induced to differentiate by retinoic acid. The expression of c-myb declined during the maturation of neuroblastoma cells, and this change was mediated by a decrease in c-myb transcription.

Indexed as

Gene Expression RegulationCell DifferentiationCell LineHumansNeuroblastomaProto-Oncogene MasProto-OncogenesRNA, MessengerTranscription, GeneticTretinoinMAS1 protein, humanProto-Oncogene MasRNA, MessengerTretinoin

Identifiers

PMID3380093
PMCPMC363328
OpenAlexW2115191618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.