Evidence map›Paper›PMID 33800865›Full record

ReviewCells2021

Functions of Dendritic Cells and Its Association with Intestinal Diseases.

Ze-Jun Yang, Bo-Ya Wang, Tian-Tian Wang, Fei-Fei Wang, Yue-Xin Guo, Rong-Xuan Hua, Hong-Wei Shang, Xin Lu, Jing-Dong Xu

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Marine drugs · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Spatial microenvironments tune immune response dynamics in thebioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. CDC42 Regulatory Patterns Related To Inflammatory Bowel Disease and Hyperglycemia.Journal of bioinformatics and systems biology : Open access · 2025
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ze-Jun YangClinical Medicine of "5 + 3" Program, Capital Medical University, Beijing 100069, China.ORCID 0000-0003-3028-6794
Bo-Ya WangUndergraduate Student of 2018 Eight Years Program of Clinical Medicine, Peking University Health Science Center, Beijing 100081, China.
Tian-Tian WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID 0000-0003-0253-0200
Fei-Fei WangClinical Medicine of "5 + 3" Program, Capital Medical University, Beijing 100069, China.
Yue-Xin GuoOral Medicine of "5 + 3" Program, Capital Medical University, Beijing 100069, China.ORCID 0000-0001-6529-6226
Rong-Xuan HuaClinical Medicine of "5 + 3" Program, Capital Medical University, Beijing 100069, China.
Hong-Wei ShangMorphological Experiment Center, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Xin LuMorphological Experiment Center, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Jing-Dong XuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Capital Medical University · CNPeking University · CN

Funding

National Key Research and Development Program of China 2016YFC1306305National Natural Science Foundation of China 81274173National Natural Science Foundation of China 81673671
6 · The paper itself

Abstract

Dendritic cells (DCs), including conventional DCs (cDCs) and plasmacytoid DCs (pDCs), serve as the sentinel cells of the immune system and are responsible for presenting antigen information. Moreover, the role of DCs derived from monocytes (moDCs) in the development of inflammation has been emphasized. Several studies have shown that the function of DCs can be influenced by gut microbes including gut bacteria and viruses. Abnormal changes/reactions in intestinal DCs are potentially associated with diseases such as inflammatory bowel disease (IBD) and intestinal tumors, allowing DCs to be a new target for the treatment of these diseases. In this review, we summarized the physiological functions of DCs in the intestinal micro-environment, their regulatory relationship with intestinal microorganisms and their regulatory mechanism in intestinal diseases.

Indexed as

AnimalsAntigens, CDBiomarkersCell DifferentiationCell LineageCytokinesDendritic CellsGastrointestinal MicrobiomeGene ExpressionHumansImmune ToleranceInflammatory Bowel DiseasesIntestinal NeoplasmsIntestinesMiceMonocytesAntigens, CDBiomarkersCytokinesdendritic cellIBDimmune toleranceintestinal floraintestinal tumor

Identifiers

PMID33800865
PMCPMC7999753
OpenAlexW3134362716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.