Evidence map›Paper›PMID 33800833›Full record

ReviewMicroorganisms2021

Contribution of Infectious Agents to the Development of Celiac Disease.

Daniel Sánchez, Iva Hoffmanová, Adéla Szczepanková, Věra Hábová, Helena Tlaskalová-Hogenová

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. New-onset celiac disease in children during COVID-19 pandemic.Acta paediatrica (Oslo, Norway : 1992) · 2022
    Article
  10. Article
  11. Review
  12. Gut microbiota in celiac disease.Annals of gastroenterology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Daniel SánchezLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences v.v.i., Vídeňská 1083, 142 20 Prague, Czech Republic.
Iva HoffmanováDepartment of Internal Medicine, University Hospital Královské Vinohrady and Third Faculty of Medicine, Charles University, Ruská 87, 100 00 Prague, Czech Republic.ORCID 0000-0002-1546-6853
Adéla SzczepankováLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences v.v.i., Vídeňská 1083, 142 20 Prague, Czech Republic.
Věra HábováLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences v.v.i., Vídeňská 1083, 142 20 Prague, Czech Republic.
Helena Tlaskalová-HogenováLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences v.v.i., Vídeňská 1083, 142 20 Prague, Czech Republic.
Czech Academy of Sciences · CZCharles University · CZ

Funding

Technology Agency of the Czech Republic TH03010019The Czech Academy of Sciences Strategy AV21-19
6 · The paper itself

Abstract

The ingestion of wheat gliadin (alcohol-soluble proteins, an integral part of wheat gluten) and related proteins induce, in genetically predisposed individuals, celiac disease (CD), which is characterized by immune-mediated impairment of the small intestinal mucosa. The lifelong omission of gluten and related grain proteins, i.e., a gluten-free diet (GFD), is at present the only therapy for CD. Although a GFD usually reduces CD symptoms, it does not entirely restore the small intestinal mucosa to a fully healthy state. Recently, the participation of microbial components in pathogenetic mechanisms of celiac disease was suggested. The present review provides information on infectious diseases associated with CD and the putative role of infections in CD development. Moreover, the involvement of the microbiota as a factor contributing to pathological changes in the intestine is discussed. Attention is paid to the mechanisms by which microbes and their components affect mucosal immunity, including tolerance to food antigens. Modulation of microbiota composition and function and the potential beneficial effects of probiotics in celiac disease are discussed.

Indexed as

celiac diseasegluten-free dietimmune responseinfectionsmicrobiotaparasites

Identifiers

PMID33800833
PMCPMC8001938
OpenAlexW3135162498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.