Evidence map›Paper›PMID 33800811›Full record

ArticleBiosensors2021

Siphon-Controlled Automation on a Lab-on-a-Disc Using Event-Triggered Dissolvable Film Valves.

Brian D Henderson, David J Kinahan, Jeanne Rio, Rohit Mishra, Damien King, Sarai M Torres-Delgado, Dario Mager, Jan G Korvink, Jens Ducrée

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Brian D HendersonSchool of Physical Sciences, Dublin City University, Dublin 9, Ireland.
David J KinahanSchool of Mechanical Engineering, Dublin City University, Dublin 9, Ireland.ORCID 0000-0003-1968-2016
Jeanne RioSchool of Physical Sciences, Dublin City University, Dublin 9, Ireland.
Rohit MishraFraunhofer Project Center, Dublin City University, Dublin 9, Ireland.
Damien KingFraunhofer Project Center, Dublin City University, Dublin 9, Ireland.
Sarai M Torres-DelgadoInstitute of Microstructure Technology, Karlsruhe Institute of Technology, 76344 Karlsruhe, Germany.
Dario MagerInstitute of Microstructure Technology, Karlsruhe Institute of Technology, 76344 Karlsruhe, Germany.ORCID 0000-0001-9487-3723
Jan G KorvinkInstitute of Microstructure Technology, Karlsruhe Institute of Technology, 76344 Karlsruhe, Germany.ORCID 0000-0003-4354-7295
Jens DucréeSchool of Physical Sciences, Dublin City University, Dublin 9, Ireland.ORCID 0000-0002-0366-1897
Dublin City University · IEKarlsruhe Institute of Technology · DEI-Form Advanced Manufacturing Research Centre · IE

Funding

Science Foundation Ireland 10/CE/B1821
6 · The paper itself

Abstract

Within microfluidic technologies, the centrifugal microfluidic "Lab-on-a-Disc" (LoaD) platform offers great potential for use at the PoC and in low-resource settings due to its robustness and the ability to port and miniaturize 'wet bench' laboratory protocols. We present the combination of 'event-triggered dissolvable film valves' with a centrifugo-pneumatic siphon structure to enable control and timing, through changes in disc spin-speed, of the release and incubations of eight samples/reagents/wash buffers. Based on these microfluidic techniques, we integrated and automated a chemiluminescent immunoassay for detection of the CVD risk factor marker C-reactive protein displaying a limit of detection (LOD) of 44.87 ng mL

Indexed as

Lab-On-A-Chip DevicesAutomationBiomarkersCardiovascular DiseasesC-Reactive ProteinEquipment DesignHumansLaboratoriesLimit of DetectionMicrofluidic Analytical TechniquesMicrofluidicsBiomarkersC-Reactive Proteincardiovascular diseasecentrifugal microfluidicschemiluminescenceimmunoassaylab-on-a-chiplab-on-a-discsiphon valves

Identifiers

PMID33800811
PMCPMC8000095
OpenAlexW3135562395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.