ArticleMicromachines2021
Characterization and Separation of Live and Dead Yeast Cells Using CMOS-Based DEP Microfluidics.
Article in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- CMOS Electrokinetic Systems and Fabrication Approaches for On-CMOS 3D Electrodes.Electrophoresis · 2026Review
- Electrophoresis: An Effective Viability Assessment Method across Cell Domains.Analytical chemistry · 2026Article
- Electronic selection of viable Legionella cells by a video-based, quantifiable dielectrophoresis approach.Biomedical microdevices · 2025Article
- A low-cost printed circuit board-based centrifugal microfluidic platform for dielectrophoresis.Microsystems & nanoengineering · 2025Article
- Analysis of Cell Dielectrophoretic Properties Using Isomotive Creek-Gap Electrode Device.Sensors (Basel, Switzerland) · 2024Article
- Portable dielectrophoresis for biology: ADEPT facilitates cell trapping, separation, and interactions.Microsystems & nanoengineering · 2024Article
- Editorial for the Special Issue on Micromachines for Dielectrophoresis, Volume II.Micromachines · 2023Article
- New Generation Dielectrophoretic-Based Microfluidic Device for Multi-Type Cell Separation.Biosensors · 2023Article
- A comprehensive review on advancements in tissue engineering and microfluidics toward kidney-on-chip.Biomicrofluidics · 2022Review
- A Novel Perturbed Spiral Sheathless Chip for Particle Separation Based on Traveling Surface Acoustic Waves (TSAW).Biosensors · 2022Article
- A Hybrid Microfluidic Electronic Sensing Platform for Life Science Applications.Micromachines · 2022Article
- Modeling Brownian Microparticle Trajectories in Lab-on-a-Chip Devices with Time Varying Dielectrophoretic or Optical Forces.Micromachines · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
This study aims at developing a miniaturized CMOS integrated silicon-based microfluidic system, compatible with a standard CMOS process, to enable the characterization, and separation of live and dead yeast cells (as model bio-particle organisms) in a cell mixture using the DEP technique. DEP offers excellent benefits in terms of cost, operational power, and especially easy electrode integration with the CMOS architecture, and requiring label-free sample preparation. This can increase the likeliness of using DEP in practical settings. In this work the DEP force was generated using an interdigitated electrode arrays (IDEs) placed on the bottom of a CMOS-based silicon microfluidic channel. This system was primarily used for the immobilization of yeast cells using DEP. This study validated the system for cell separation applications based on the distinct responses of live and dead cells and their surrounding media. The findings confirmed the device's capability for efficient, rapid and selective cell separation. The viability of this CMOS embedded microfluidic for dielectrophoretic cell manipulation applications and compatibility of the dielectrophoretic structure with CMOS production line and electronics, enabling its future commercially mass production.
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Registered trials
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