Observational studyMolecules (Basel, Switzerland)2021
Comparison of Anticoagulation Quality between Acenocoumarol and Warfarin in Patients with Mechanical Prosthetic Heart Valves: Insights from the Nationwide PLECTRUM Study.
Observational study in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Comparison of the Direct Oral Anticoagulants and Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.Frontiers in cardiovascular medicine · 2021Pooled it
- Article
- Treatment Stability of Warfarin and Acenocoumarol in Patients With Mechanical Heart Valves and Atrial Fibrillation: A One-Year Cohort Study.Acta medica academica · 2026Article
- Oxidative Stress Related to Mechanical Heart Valves: A Pilot Cross-Sectional Study.Antioxidants (Basel, Switzerland) · 2025Article
- Antithrombotic therapy and the risk of pocket hematoma after subcutaneous implantable cardioverter-defibrillator implantation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Cost-effectiveness of dabigatran for thromboembolic events prevention in atrial fibrillation patients in Chile.Cost effectiveness and resource allocation : C/E · 2025Article
- Outcomes of Patients with a Mechanical Heart Valve and Poor Anticoagulation Control on Warfarin.Thrombosis and haemostasis · 2024Article
- Frequency of prothrombin time-international normalized ratio monitoring and the long-term prognosis in patients with mechanical valve replacement.BMC cardiovascular disorders · 2023Observational
- Administration of Warfarin Inhibits the Development of Cerulein-Induced Edematous Acute Pancreatitis in Rats.Biomolecules · 2023Article
- Anticoagulation Control and Major Adverse Clinical Events in Patients with Operated Valvular Heart Disease with and without Atrial Fibrillation Receiving Vitamin K Antagonists.Journal of clinical medicine · 2023Article
- Recent Advances in Biologically Active Coumarins from Marine Sources: Synthesis and Evaluation.Marine drugs · 2022Review
- Do Oral Factor Xa Inhibitors have a Role in Patients with Mechanical Heart Valves?American journal of cardiovascular drugs : drugs, devices, and other interventions · 2022Review
- Coumarin and Its Derivatives-Editorial.Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin K antagonists are indicated for the thromboprophylaxis in patients with mechanical prosthetic heart valves (MPHV). However, it is unclear whether some differences between acenocoumarol and warfarin in terms of anticoagulation quality do exist. We included 2111 MPHV patients included in the nationwide PLECTRUM registry. We evaluated anticoagulation quality by the time in therapeutic range (TiTR). Factors associated with acenocoumarol use and with low TiTR were investigated by multivariable logistic regression analysis. Mean age was 56.8 ± 12.3 years; 44.6% of patients were women and 395 patients were on acenocoumarol. A multivariable logistic regression analysis showed that patients on acenocoumarol had more comorbidities (i.e., ≥3, odds ratio (OR) 1.443, 95% confidence interval (CI) 1.081-1.927,
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