Evidence map›Paper›PMID 33800709›Full record

ReviewInternational journal of molecular sciences2021

Recent Progress on Biodegradable Tissue Engineering Scaffolds Prepared by Thermally-Induced Phase Separation (TIPS).

Reza Zeinali, Luis J Del Valle, Joan Torras, Jordi Puiggalí

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  17. Bio-Informed Porous Mineral-Based Composites.Small (Weinheim an der Bergstrasse, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Reza ZeinaliDepartament d'Enginyeria Química, Universitat Politècnica de Catalunya, Escola d'Enginyeria de Barcelona Est-EEBE, 08019 Barcelona, Spain.
Luis J Del ValleDepartament d'Enginyeria Química, Universitat Politècnica de Catalunya, Escola d'Enginyeria de Barcelona Est-EEBE, 08019 Barcelona, Spain.ORCID 0000-0001-9916-1741
Joan TorrasDepartament d'Enginyeria Química, Universitat Politècnica de Catalunya, Escola d'Enginyeria de Barcelona Est-EEBE, 08019 Barcelona, Spain.ORCID 0000-0001-8737-7609
Jordi PuiggalíDepartament d'Enginyeria Química, Universitat Politècnica de Catalunya, Escola d'Enginyeria de Barcelona Est-EEBE, 08019 Barcelona, Spain.

Funding

Generalitat de Catalunya 2017SGR373Ministerio de Economía, Industria y Competitividad, Gobierno de España RTI2018-101827-B-I00
6 · The paper itself

Abstract

Porous biodegradable scaffolds provide a physical substrate for cells allowing them to attach, proliferate and guide the formation of new tissues. A variety of techniques have been developed to fabricate tissue engineering (TE) scaffolds, among them the most relevant is the thermally-induced phase separation (TIPS). This technique has been widely used in recent years to fabricate three-dimensional (3D) TE scaffolds. Low production cost, simple experimental procedure and easy processability together with the capability to produce highly porous scaffolds with controllable architecture justify the popularity of TIPS. This paper provides a general overview of the TIPS methodology applied for the preparation of 3D porous TE scaffolds. The recent advances in the fabrication of porous scaffolds through this technique, in terms of technology and material selection, have been reviewed. In addition, how properties can be effectively modified to serve as ideal substrates for specific target cells has been specifically addressed. Additionally, examples are offered with respect to changes of TIPS procedure parameters, the combination of TIPS with other techniques and innovations in polymer or filler selection.

Indexed as

AnimalsBiocompatible MaterialsHumansMaterials TestingMicroscopy, Electron, ScanningPolyestersPolymersPorositySolventsTemperatureTissue EngineeringTissue ScaffoldsBiocompatible MaterialspolycaprolactonePolyesterspoly(lactide)PolymersSolventsbiodegradable polymercompositesmorphologypore structureporosityprocessing parametersthermally induced phase separationtissue engineering scaffold

Identifiers

PMID33800709
PMCPMC8036748

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.