Evidence map›Paper›PMID 33800490›Full record

SynthesisInternational journal of molecular sciences2021

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome-A Systematic Review and Meta-Analysis.

Shaimaa Aboeldalyl, Cathryn James, Emaduldin Seyam, Emad Moussa Ibrahim, Hossam El-Din Shawki, Saad Amer

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05410834 (The Characterization of Pro-vascular Regenerative Cell Exhaustion in Women With Polycystic Ovarian Syndrome), which is not on this map. Cited by 121 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 6 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05410834 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Characterization of Pro-vascular Regenerative Cell Exhaustion in Women With Polycystic Ovarian Syndrome

TypeobservationalSponsorCanadian Medical and Surgical Knowledge Translation Research GroupRan2022 to 2023Enrolled30ConditionsPolycystic Ovary Syndrome
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 6 syntheses or guidelines pooled it, 205 citations in OpenAlex.

  1. Pooled it
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  15. Review
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  19. Review
  20. Back to the Drawing Board: Rethinking Inflammation in Polycystic Ovary Syndrome.The Journal of clinical endocrinology and metabolism · 2026
    Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Shaimaa AboeldalylAcademic Unit of Translational Medical Sciences, School of Medicine, Royal Derby Hospital Centre, University of Nottingham, Derby DE22 3DT, UK.
Cathryn JamesUniversity Hospitals of Derby and Burton NHS Foundation Trust, Library & Knowledge Service, Derby DE22 3NT, UK.
Emaduldin SeyamFaculty of Medicine, Obstetrics and Gynaecology, University of Minia, Minia 61519, Egypt.
Emad Moussa IbrahimFaculty of Medicine, Obstetrics and Gynaecology, University of Minia, Minia 61519, Egypt.
Hossam El-Din ShawkiFaculty of Medicine, Obstetrics and Gynaecology, University of Minia, Minia 61519, Egypt.
Saad AmerAcademic Unit of Translational Medical Sciences, School of Medicine, Royal Derby Hospital Centre, University of Nottingham, Derby DE22 3DT, UK.ORCID 0000-0001-8321-1302
Minia University · EGUniversity of Nottingham · GBUniversity Hospitals of Derby and Burton NHS Foundation Trust · GB

Funding

Egyptian Cultural Center and Education bureau in London n/a
6 · The paper itself

Abstract

Although the current literature associates polycystic ovarian syndrome (PCOS) with chronic inflammation, the evidence for this link remains inconclusive and its causal nature remains unclear. The purpose of this systematic review was to assess the inflammatory status in PCOS women and to determine whether it is related to PCOS or to its associated adiposity. We searched electronic databases including PUBMED, EMBASE and MEDLINE, SCOPUS, DynaMed plus, TRIP, ScienceDirect and Cochrane Library, for studies investigating C-reactive protein (CRP) and other inflammatory makers in PCOS women versus healthy controls. Quality and risk of bias for selected studies were assessed using the modified Newcastle-Ottawa scale. CRP data were extracted and pooled using RevMan for calculation of the standardized mean difference (SMD) and 95% confidence interval (CI). Eighty-five eligible studies were included in the systematic review, of which 63 were included in the meta-analysis. Pooled analysis of the 63 studies revealed significantly higher circulating CRP in PCOS women (

Indexed as

Chronic DiseaseC-Reactive ProteinFemaleHumansInflammationObesityPolycystic Ovary SyndromeC-Reactive Proteinchronic inflammationC-reactive proteininflammatory markersinsulin resistanceobesitypolycystic ovarian syndrome

Identifiers

PMID33800490
PMCPMC7962967
OpenAlexW3134983130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.