Evidence map›Paper›PMID 33800406›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Increase in Tuberculosis Diagnostic Delay during First Wave of the COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital.

Francesco Di Gennaro, Gina Gualano, Laura Timelli, Pietro Vittozzi, Virginia Di Bari, Raffaella Libertone, Carlotta Cerva, Luigi Pinnarelli, Carla Nisii, Stefania Ianniello and 10 more

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Lived experiences of tuberculosis patients accessing treatment during COVID-19 in Zimbabwe.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026
    Article
  6. Impact of the COVID-19 pandemic on tuberculosis program performance in Alberta, Canada: a population-based evaluation.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
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  12. Article
  13. Impact on tuberculosis diagnostic during COVID-19 pandemic in a tertiary care hospital.Enfermedades infecciosas y microbiologia clinica (English ed.) · 2024
    Observational
  14. Article
  15. Article
  16. Article
  17. A critical analysis of the decreasing trends in tuberculosis cure indicators in Brazil, 2001-2022.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024
    Article
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Francesco Di GennaroNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.ORCID 0000-0003-3453-5647
Gina GualanoNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.
Laura TimelliNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.ORCID 0000-0003-2306-0260
Pietro VittozziNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.
Virginia Di BariNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.
Raffaella LibertoneNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.
Carlotta CervaNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.ORCID 0000-0001-9060-7313
Luigi PinnarelliDepartment of Epidemiology of Lazio Regional Health Service, 00147 Rome, Italy.
Carla NisiiNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.ORCID 0000-0001-5369-0437
Stefania IannielloNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.
Silvia MostiNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.
Nazario BevilacquaNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.
Fabio IacomiNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.
Annalisa MondiNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.
Simone TopinoNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.
Delia GolettiNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.ORCID 0000-0001-8360-4376
Francesco VaiaNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.
Giuseppe IppolitoNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.ORCID 0000-0002-1076-2979
Enrico GirardiNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.ORCID 0000-0001-8182-5896
Fabrizio PalmieriNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00161 Rome, Italy.ORCID 0000-0001-8184-6291

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe WHO advised that the impact of COVID-19 pandemic on TB services was estimated to be dramatic due to the disruption of TB services.

methodsA retrospective data collection and evaluation was conducted to include all the patients hospitalized for TB at INMI from 9 March to 31 August 2020 (lockdown period and three months thereafter). For the purpose of the study, data from patients hospitalized in the same period of 2019 were also collected.

resultsIn the period of March-August 2019, 201 patients were hospitalized with a diagnosis of TB, while in the same period of 2020, only 115 patients, with a case reduction of 43%. Patients with weight loss, acute respiratory failure, concurrent extrapulmonary TB, and higher Timika radiographic scores were significantly more frequently hospitalized during 2020 vs. 2019. The median patient delay was 75 days (IQR: 40-100) in 2020 compared to 30 days (IQR: 10-60) in 2019 (

conclusionsOur experience suggests that COVID-19 pandemic had an impact on TB patient care in terms of higher diagnostic delay, reduction in hospitalization, and a greater severity of clinical presentations.

Indexed as

COVID 19diagnostic delaypandemicSARS CoV2tuberculosis

Identifiers

PMID33800406
PMCPMC7998965

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.