Evidence map›Paper›PMID 33800294›Full record

ArticleJournal of clinical medicine2021

Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer.

Michał Szczyrek, Radosław Mlak, Aneta Szudy-Szczyrek, Karolina Kędziora, Teresa Małecka-Massalska, Paweł Krawczyk, Janusz Milanowski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michał SzczyrekDepartment of Pneumonology, Oncology and Allergology, Medical University of Lublin, 20-090 Lublin, Poland.ORCID 0000-0002-1271-2254
Radosław MlakDepartment of Human Physiology, Medical University of Lublin, 20-080 Lublin, Poland.ORCID 0000-0001-7399-8340
Aneta Szudy-SzczyrekDepartment of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-081 Lublin, Poland.
Karolina KędzioraCollegium Medicum, University of Zielona Góra, 64-064 Zielona Góra, Poland.
Teresa Małecka-MassalskaDepartment of Human Physiology, Medical University of Lublin, 20-080 Lublin, Poland.ORCID 0000-0003-3384-0324
Paweł KrawczykDepartment of Pneumonology, Oncology and Allergology, Medical University of Lublin, 20-090 Lublin, Poland.
Janusz MilanowskiDepartment of Pneumonology, Oncology and Allergology, Medical University of Lublin, 20-090 Lublin, Poland.
Medical University of Lublin · PLUniversity of Zielona Góra · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caspase 8 is a protein involved in the process of cell apoptosis, which may affect the efficacy of anti-cancer treatment. The aim of our study was to determine the impact of polymorphisms in the

Indexed as

CASP-8caspase 8NSCLCplatinumpolymorphism

Identifiers

PMID33800294
PMCPMC7962636
OpenAlexW3135151431

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.