ReviewBrain sciences2021
What Do We Know about the Long-Term Course of Early Onset Bipolar Disorder? A Review of the Current Evidence.
Review in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- Comparative Analysis of the Burden of Bipolar Disorder Among Individuals Aged 15-49 Years in China and Globally, 1990-2021: An Ecological Trend Analysis Based on GBD 2021.Health science reports · 2026Article
- Diagnosis-Specific Clinical and Longitudinal Predictors of Suicide Attempts in Early-Onset Mood Disorders.Psychiatry investigation · 2026Article
- Test of the reward/circadian rhythm dysregulation model of risk for bipolar spectrum disorders at a micro time scale using multilevel moderated mediation.Journal of psychopathology and clinical science · 2026Article
- Relapse rate and predictors among people with severe mental illnesses at Debre Markos Comprehensive specialized hospital, Northwest Ethiopia: a prospective follow up study.European archives of psychiatry and clinical neuroscience · 2026Article
- Co-designing and piloting adolescent-adapted social rhythm therapy for young people with unipolar and bipolar depression: a mixed-methods feasibility case series.Frontiers in child and adolescent psychiatry · 2026Article
- Advancing the prediction of factors associated with bipolar disorder risk: utilizing early recognition tools and polygenic risk scores.International journal of bipolar disorders · 2025Article
- Reward Sensitivity, Pubertal Development, and Circadian Rhythms: A Window into Adolescent Risk for Depressive Symptoms.Journal of youth and adolescence · 2025Article
- Prediction of early-onset bipolar using electronic health records.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Screen time and manic symptoms in early adolescents: prospective findings from the Adolescent Brain Cognitive Development Study.Social psychiatry and psychiatric epidemiology · 2025Article
- Error monitoring and response inhibition in adolescents with bipolar disorders: An ERP study.Cognitive, affective & behavioral neuroscience · 2025Article
- Aggressive Behavior in Children and Adolescents With Bipolar Spectrum Disorder: A Systematic Review of the Prevalence, Associated Factors, and Treatment.JAACAP open · 2025Review
- Consumers with bipolar disorder presenting to an Australian child and youth mental health service.Frontiers in psychiatry · 2025Article
- Investigating the frequency of tick-borne infections in a case series of 37 youth diagnosed with pediatric bipolar disorder.Frontiers in child and adolescent psychiatry · 2025Article
- Hospital-treated bipolar disorder in adolescence in Finland 1980-2010: Rehospitalizations, diagnostic stability, and mortality.Bipolar disorders · 2024Article
- Aripiprazole once-monthly for the treatment of adult patients with earlier-stage bipolar I disorder: a post hoc analysis of data from a double-blind, placebo-controlled, 52-week randomized withdrawal trial.International journal of bipolar disorders · 2024Article
- VEGF, IGF-1 and FGF-2 Serum Levels in Children and Adolescents with Autism Spectrum Disorder with and without Bipolar Disorder.Journal of autism and developmental disorders · 2024Article
- Sensation Seeking in Children and Adults with Pediatric-Onset Bipolar Disorder.Child psychiatry and human development · 2024Article
- Composite immune marker scores associated with severe mental disorders and illness course.Brain, behavior, & immunity - health · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimEarly onset of psychopathology is often an index of a more severe clinical course and worse prognosis. This review examined the course of bipolar disorder (BD) with onset in childhood and adolescence, with a focus on persistence of symptoms, severity of illness, comorbidity, and functional impairment.
methodsThe databases of PubMed, Embase, and PsycInfo were systematically searched for publications since 1990 reporting on long-term (12 months or longer) assessments of patients with early onset BD.
resultsForty-two relevant publications were identified, which reported on data derived from 15 different patient cohorts, including 7 prospective research psychopathology studies, 4 medical record reviews, 2 follow-ups of clinical trial samples, 1 managed care database, and 1 nationwide registry, for a total of 10,187 patients. The length of follow-ups ranged from 1.0 to 15 years. Diagnostic stability of BD ranged from 73% to 100% over ten years. Recovery rate from an index episode was 81.5-100% and recurrence rate was 35-67%. Suicide attempt cumulative prevalence in five years was 18-20%. Earlier age at the first episode predicted a more severe clinical course.
conclusionsEarly onset BD persists over time through adolescence, with homotypic diagnostic continuity over the years, but heterogeneity in the severity of the clinical course. Whether early identification and treatment improves distal prognosis remains to be further investigated.
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