Evidence map›Paper›PMID 33800236›Full record

ReviewCancers2021

Novel Cytotoxic Chemotherapies in Small Cell Lung Carcinoma.

Diego Cortinovis, Paolo Bidoli, Stefania Canova, Francesca Colonese, Maria Gemelli, Maria Luisa Lavitrano, Giuseppe Luigi Banna, Stephen V Liu, Alessandro Morabito

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Diego CortinovisDepartment Medical Oncology-ASST-Monza Ospedale San Gerardo, via Pergolesi 33, 20090 Monza, Italy.ORCID 0000-0001-7611-7369
Paolo BidoliDepartment Medical Oncology-ASST-Monza Ospedale San Gerardo, via Pergolesi 33, 20090 Monza, Italy.
Stefania CanovaDepartment Medical Oncology-ASST-Monza Ospedale San Gerardo, via Pergolesi 33, 20090 Monza, Italy.
Francesca ColoneseDepartment Medical Oncology-ASST-Monza Ospedale San Gerardo, via Pergolesi 33, 20090 Monza, Italy.
Maria GemelliDepartment Medical Oncology-ASST-Monza Ospedale San Gerardo, via Pergolesi 33, 20090 Monza, Italy.ORCID 0000-0003-1143-0252
Maria Luisa LavitranoSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0003-4852-1318
Giuseppe Luigi BannaDepartment of Oncology, Portsmouth Hospitals University NHS Trust, Cosham, Portsmouth PO6 3LY, UK.ORCID 0000-0003-0764-3650
Stephen V LiuLombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC 20007, USA.ORCID 0000-0002-4852-3914
Alessandro MorabitoSC Oncologia Medica Toraco-Polmonare, IRCCS Istituto Nazionale dei Tumori, Fondazione Pascale, 80100 Napoli, Italy.ORCID 0000-0002-1319-9608
Azienda Ospedaliera San Gerardo · ITGeorgetown University · USIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITPortsmouth Hospitals NHS Trust · GBUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small cell lung cancer (SCLC) is one of the deadliest thoracic neoplasms, in part due to its fast doubling time and early metastatic spread. Historically, cytotoxic chemotherapy consisting of platinum-etoposide or anthracycline-based regimens has demonstrated a high response rate, but early chemoresistance leads to a poor prognosis in advanced SCLC. Only a fraction of patients with limited-disease can be cured by chemo-radiotherapy. Given the disappointing survival rates in advanced SCLC, new cytotoxic agents are eagerly awaited. Unfortunately, few novel chemotherapy drugs have been developed in the latest decades. This review describes the results and potential application in the clinical practice of novel chemotherapy agents for SCLC.

Indexed as

chemotherapyimmunotherapylurbinectedinsmall cell lung cancer

Identifiers

PMID33800236
PMCPMC7962524
OpenAlexW3134632399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.