Evidence map›Paper›PMID 33800069›Full record

ArticleMolecules (Basel, Switzerland)2021

The Complex Structure of Protein AaLpxC from

Shuai Fan, Danyang Li, Maocai Yan, Xiao Feng, Guangxin Lv, Guangteng Wu, Yuanyuan Jin, Yucheng Wang, Zhaoyong Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Novel Antibacterial Approaches and Therapeutic Strategies.Antibiotics (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shuai FanInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Danyang LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Maocai YanSchool of Pharmacy, Jining Medical University, Rizhao, Shandong 276800, China.ORCID 0000-0002-1117-9398
Xiao FengInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Guangxin LvInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Guangteng WuArNuXon Pharm-Sci Co., Ltd., Beijing 100085, China.
Yuanyuan JinInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Yucheng WangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Zhaoyong YangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNJining Medical University · CN

Funding

CAMS Innovation Fund for Medical Sciences 2019-I2M-1-005National Key Research and Development Program of China 2018YFA0901800National Natural Science Foundation of China 81761128016National Natural Science Foundation of China 8187131584Open Project of Beijing Key Laboratory of Antimicrobial Agents 2019BJZDS004
6 · The paper itself

Abstract

New drugs with novel antibacterial targets for Gram-negative bacterial pathogens are desperately needed. The protein LpxC is a vital enzyme for the biosynthesis of lipid A, an outer membrane component of Gram-negative bacterial pathogens. The ACHN-975 molecule has high enzymatic inhibitory capacity against the infectious diseases, which are caused by multidrug-resistant bacteria, but clinical research was halted because of its inflammatory response in previous studies. In this work, the structure of the recombinant UDP-3-

Indexed as

AmidohydrolasesAnti-Bacterial AgentsAquifexBacterial ProteinsBenzamidesBinding SitesCalorimetryCrystallography, X-RayGram-Negative BacteriaProtein ConformationThermodynamicsACHN-975AmidohydrolasesAnti-Bacterial AgentsBacterial ProteinsBenzamidesUDP-3-O-acyl-N-acetylglucosamine deacetylaseACHN-975crystal structure ITCdrug designLpxCX-ray crystallography

Identifiers

PMID33800069
PMCPMC7962117
OpenAlexW3135609344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.