ArticleBiomedicines2021
Isolation and Characterization of Buccal Fat Pad and Dental Pulp MSCs from the Same Donor.
Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Comparative Evaluation of the Functional Potential of Mesenchymal Stem Cells from the Bichat's Fat Pad, Bone Marrow, and Adipose Tissue for Bone Tissue Regeneration.Bulletin of experimental biology and medicine · 2025Article
- Oral stem cells in combination with hydrogels as biomimetic bioactive platforms for periodontal tissue engineering.Frontiers in oral health · 2025Review
- Osteoblast Response to Widely Ranged Texturing Conditions Obtained through High Power Laser Beams on Ti Surfaces.Journal of functional biomaterials · 2024Article
- The Buccal Fat Pad: A Unique Human Anatomical Structure and Rich and Easily Accessible Source of Mesenchymal Stem Cells for Tissue Repair.Bioengineering (Basel, Switzerland) · 2024Review
- Insights and Advancements in Periodontal Tissue Engineering and Bone Regeneration.Medicina (Kaunas, Lithuania) · 2024Review
- Dental-derived stem cells in tissue engineering: the role of biomaterials and host response.Regenerative biomaterials · 2024Review
- Histomorphometric Evaluation of New Bone Formation, Dimensional Changes, and Residual Particles in Alveolar Ridge Preservation Techniques Using InterOss® Anorganic Cancellous Bone Graft: A Longitudinal Study.International journal of dentistry · 2024Article
- Exploring Various Transfection Approaches and Their Applications in Studying the Regenerative Potential of Dental Pulp Stem Cells.Current issues in molecular biology · 2023Review
- State of the Art and New Trends from the 2022 Gism Annual Meeting.International journal of molecular sciences · 2023Article
- Isolation and cultivation as well asFrontiers in veterinary science · 2023Article
- Assessment of angiogenic potential of mesenchymal stem cells derived conditioned medium from various oral sources.Journal of clinical and translational research · 2022Article
- Molecular Biological Comparison of Dental Pulp- and Apical Papilla-Derived Stem Cells.International journal of molecular sciences · 2022Article
- Intra-Individual Variability of Human Dental Pulp Stem Cell Features Isolated from the Same Donor.International journal of molecular sciences · 2021Article
- Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesenchymal stem cells (MSCs) can be harvested from different sites in the oral cavity, representing a reservoir of cells useful for regenerative purposes. As direct comparisons between at least two types of MSCs deriving from the same patient are surprisingly rare in scientific literature, we isolated and investigated the osteoinductive potential of dental pulp stem cells (DPSCs) and buccal fat pad stem cells (BFPSCs). MSCs were isolated from the third molar dental pulp and buccal fat pads of 12 patients. The number of viable cells was quantified through manual count. Proliferation and osteodifferentiation assays, flow cytometry analysis of cell phenotypes, and osteocalcin release in vitro were performed. The isolation of BFPSCs and DPSCs was successful in 7 out of 12 (58%) and 3 out of 12 (25%) of retrieved samples, respectively. The yield of cells expressing typical stem cell markers and the level of proliferation were higher in BFPSCs than in DPSCs. Both BFP-SCs and DPSCs differentiated into osteoblast-like cells and were able to release a mineralized matrix. The release of osteocalcin, albeit greater for BFPSCs, did not show any significant difference between BFPSCs and DPSCs. The yield of MSCs depends on their site of origin as well as on the protocol adopted for their isolation. Our data show that BFP is a valuable source for the derivation of MSCs that can be used for regenerative treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.