ArticleCancers2021
Intratumor Heterogeneity in Uveal Melanoma BAP-1 Expression.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Article
- Prognostic value of BAP1 expression in uveal melanoma: a comparative study with histopathological factors in a large Spanish cohort.Frontiers in oncology · 2026Article
- Dualistic Role of MITF in Uveal Melanoma: Defining Two Distinct Cellular Subpopulations With Prognostic and Therapeutic Implications.Investigative ophthalmology & visual science · 2025Article
- Immunohistochemical expression of smoothened in periocular basal cell, squamous cell and sebaceous carcinomas.Scientific reports · 2025Article
- Quantitative Perfusion-Weighted Magnetic Resonance Imaging in Uveal Melanoma.Investigative ophthalmology & visual science · 2024Article
- The Pediatric and Young Adult Choroidal and Ciliary Body Melanoma Genetic Study, A Survey by the European Ophthalmic Oncology Group.Investigative ophthalmology & visual science · 2024Observational
- Expression of GNAQ, BAP1, SF3B1, and EIF1AX Proteins in the Aqueous Humor of Eyes Affected by Uveal Melanoma.Investigative ophthalmology & visual science · 2024Article
- Tumor Profiles of Late Presentation Uveal Ring Melanoma With Novel Characteristics - A Case Series.Investigative ophthalmology & visual science · 2023Article
- Digital morphometry and cluster analysis identifies four types of melanocyte during uveal melanoma progression.Communications medicine · 2023Article
- Need for a Dedicated Ophthalmic Malignancy Clinico-Biological Biobank: The Nice Ocular MAlignancy (NOMA) Biobank.Cancers · 2023Review
- A serum protein signature at the time of Uveal Melanoma diagnosis predicts long-term patient survival.BMC cancer · 2023Article
- Genetics and RNA Regulation of Uveal Melanoma.Cancers · 2023Review
- The prognostic implication of latitude in uveal melanoma: a nationwide observational cohort study of all patients born in Sweden between 1947 and 1989.Discover oncology · 2022Article
- Trends in Uveal Melanoma Presentation and Survival During Five Decades: A Nationwide Survey of 3898 Swedish Patients.Frontiers in medicine · 2022Article
- Integration of Bulk RNA Sequencing and Single-Cell RNA Sequencing to Reveal Uveal Melanoma Tumor Heterogeneity and Cells Related to Survival.Frontiers in immunology · 2022Article
- Estimation of the timing of BAP1 mutation in uveal melanoma progression.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Malignant tumors are rarely homogenous on the morphological, genome, transcriptome or proteome level. In this study, we investigate the intratumor heterogeneity of BAP-1 expression in uveal melanoma with digital image analysis of 40 tumors. The proportion of BAP-1 positive cells was measured in full tumor sections, hot spots, cold spots and in scleral margins. The mean difference between hot spots and cold spots was 41 percentage points (pp, SD 29). Tumors with gene expression class 1 (associated with low metastatic risk) and 2 (high metastatic risk) had similar intratumor heterogeneity. Similarly, the level of intratumor heterogeneity was comparable in tumors from patients that later developed metastases as in patients that did not. BAP-1 measured in any tumor region added significant prognostic information to both American Joint Committee on Cancer (AJCC) tumor size category (
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