Evidence map›Paper›PMID 33800006›Full record

ReviewJournal of clinical medicine2021

Platelet Phenotyping and Function Testing in Thrombocytopenia.

Kerstin Jurk, Yavar Shiravand

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Human Disabled-2 regulates thromboxane ANature communications · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Identification of High Platelet Reactivity Despite ADP P2YTH open : companion journal to thrombosis and haemostasis · 2023
    Article
  10. NovelCells · 2022
    Article
  11. Platelet function testing: Current practice among clinical centres in Northern Europe.Haemophilia : the official journal of the World Federation of Hemophilia · 2022
    Article
  12. Neonatal Sepsis and Hemostasis.Diagnostics (Basel, Switzerland) · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Kerstin JurkCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.ORCID 0000-0001-5313-4035
Yavar ShiravandDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Johannes Gutenberg University Mainz · DEUniversity of Naples Federico II · IT

Funding

Bundesministerium für Bildung und Forschung 01EO1003Bundesministerium für Bildung und Forschung 01EO1503
6 · The paper itself

Abstract

Patients who suffer from inherited or acquired thrombocytopenia can be also affected by platelet function defects, which potentially increase the risk of severe and life-threatening bleeding complications. A plethora of tests and assays for platelet phenotyping and function analysis are available, which are, in part, feasible in clinical practice due to adequate point-of-care qualities. However, most of them are time-consuming, require experienced and skilled personnel for platelet handling and processing, and are therefore well-established only in specialized laboratories. This review summarizes major indications, methods/assays for platelet phenotyping, and in vitro function testing in blood samples with reduced platelet count in relation to their clinical practicability. In addition, the diagnostic significance, difficulties, and challenges of selected tests to evaluate the hemostatic capacity and specific defects of platelets with reduced number are addressed.

Indexed as

bleedingflow cytometryplatelet countplatelet disordersplatelet function teststhrombocytopenia

Identifiers

PMID33800006
PMCPMC7962106
OpenAlexW3134546622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.