Evidence map›Paper›PMID 33799946›Full record

ReviewInternational journal of molecular sciences2021

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia.

Princess D Rodriguez, Hana Paculova, Sophie Kogut, Jessica Heath, Hilde Schjerven, Seth Frietze

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Age-Driven Genetic and Epigenetic Heterogeneity in B-ALL.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Expression Profiles of Long Non-Coding RNADiagnostics (Basel, Switzerland) · 2021
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Princess D RodriguezDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, VT 05405, USA.
Hana PaculovaDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0002-4719-723X
Sophie KogutDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, VT 05405, USA.
Jessica HeathThe University of Vermont Cancer Center, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0003-1771-2242
Hilde SchjervenDepartment of Laboratory Medicine, University of California, San Francisco, CA 94143, USA.
Seth FrietzeDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0003-4058-3661
University of Vermont · USUniversity of California, San Francisco · US

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Kimberly Luebbers · 2017 to 2026
$51.6M
Vermont Immunology/Infectious Diseases Training GrantT32AI055402 · NIAID · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI GARY E WARD · 2005 to 2026
$2.7M
Understanding Ikaros molecular functions for targeted therapies of pre-B ALLR01CA230618 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRIETZE, SETH E, SCHJERVEN, HILDE · 2018 to 2022
$1.8M
Mechanism of Ikaros Tumor Suppression in progenitor B cell leukemiaR21CA209229 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRIETZE, SETH E, SCHJERVEN, HILDE · 2016 to 2017
$420k
NCI NIH HHS R01 CA230618NCI NIH HHS R21 CA209229NIAID NIH HHS T32 AI055402NIH HHS R01CA230618NIH HHS R21CA209229
6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs) comprise a diverse class of non-protein coding transcripts that regulate critical cellular processes associated with cancer. Advances in RNA-sequencing (RNA-Seq) have led to the characterization of non-coding RNA expression across different types of human cancers. Through comprehensive RNA-Seq profiling, a growing number of studies demonstrate that ncRNAs, including long non-coding RNA (lncRNAs) and microRNAs (miRNA), play central roles in progenitor B-cell acute lymphoblastic leukemia (B-ALL) pathogenesis. Furthermore, due to their central roles in cellular homeostasis and their potential as biomarkers, the study of ncRNAs continues to provide new insight into the molecular mechanisms of B-ALL. This article reviews the ncRNA signatures reported for all B-ALL subtypes, focusing on technological developments in transcriptome profiling and recently discovered examples of ncRNAs with biologic and therapeutic relevance in B-ALL.

Indexed as

Drug Resistance, NeoplasmGene Expression ProfilingGene Expression Regulation, LeukemicGlucocorticoidsHumansMicroRNAsPrecursor B-Cell Lymphoblastic Leukemia-LymphomaRNA, Long NoncodingRNA, UntranslatedGlucocorticoidsMicroRNAsRNA, Long NoncodingRNA, UntranslatedB-cellleukemianon-codingRNA-sequencingsmall RNA-sequencing

Identifiers

PMID33799946
PMCPMC7961854
OpenAlexW3134587293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.