Evidence map›Paper›PMID 33799902›Full record

ArticleMolecules (Basel, Switzerland)2021

In-Vitro Cytotoxicity Study: Cell Viability and Cell Morphology of Carbon Nanofibrous Scaffold/Hydroxyapatite Nanocomposites.

Asmaa M Abd El-Aziz, Azza El-Maghraby, Andrea Ewald, Sherif H Kandil

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Asmaa M Abd El-AzizFabrication Technology Research Department, Advanced Technology and New Materials Research Institute, City for Scientific Research and Technological Applications, Alexandria 23713, Egypt.ORCID 0000-0002-6100-668X
Azza El-MaghrabyFabrication Technology Research Department, Advanced Technology and New Materials Research Institute, City for Scientific Research and Technological Applications, Alexandria 23713, Egypt.
Andrea EwaldDepartment of Functional Materials in Medicine and Dentistry, University Hospital Würzburg Center for Dental, Würzburg University, 97070 Würzburg, Germany.
Sherif H KandilDepartment of Materials Science, Institute of Graduate Studies and Research, Alexandria University, Alexandria 21526, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrospun carbon nanofibers (CNFs), which were modified with hydroxyapatite, were fabricated to be used as a substrate for bone cell proliferation. The CNFs were derived from electrospun polyacrylonitrile (PAN) nanofibers after two steps of heat treatment: stabilization and carbonization. Carbon nanofibrous (CNF)/hydroxyapatite (HA) nanocomposites were prepared by two different methods; one of them being modification during electrospinning (CNF-8HA) and the second method being hydrothermal modification after carbonization (CNF-8HA; hydrothermally) to be used as a platform for bone tissue engineering. The biological investigations were performed using in-vitro cell counting, WST cell viability and cell morphology after three and seven days. L929 mouse fibroblasts were found to be more viable on the hydrothermally-modified CNF scaffolds than on the unmodified CNF scaffolds. The biological characterizations of the synthesized CNF/HA nanofibrous composites indicated higher capability of bone regeneration.

Indexed as

AnimalsBone and BonesBone DevelopmentBone RegenerationCarbonCell LineCell SurvivalDurapatiteFibroblastsMiceNanocompositesNanofibersNanotubes, CarbonOsteoblastsOsteogenesisTissue EngineeringCarbonDurapatiteNanotubes, Carboncell countingcell morphologycell viabilitycytotoxicityHA modifiedCNF membranesWST test

Identifiers

PMID33799902
PMCPMC7999924

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.