Evidence map›Paper›PMID 33799860›Full record

ArticleBiomolecules2021

Pharmacological and Genetic Evidence of Dopamine Receptor 3-Mediated Vasoconstriction in Isolated Mouse Aorta.

Veronica Zingales, Sebastiano Alfio Torrisi, Gian Marco Leggio, Claudio Bucolo, Filippo Drago, Salvatore Salomone

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as DInternational journal of molecular sciences · 2025
    Article
  3. Dopamine, Immunity, and Disease.Pharmacological reviews · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Veronica ZingalesDepartment of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia 97, 95123 Catania, Italy.ORCID 0000-0002-5391-870X
Sebastiano Alfio TorrisiDepartment of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia 97, 95123 Catania, Italy.ORCID 0000-0002-6920-439X
Gian Marco LeggioDepartment of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia 97, 95123 Catania, Italy.ORCID 0000-0002-7280-4871
Claudio BucoloDepartment of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia 97, 95123 Catania, Italy.ORCID 0000-0002-4879-4140
Filippo DragoDepartment of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia 97, 95123 Catania, Italy.
Salvatore SalomoneDepartment of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia 97, 95123 Catania, Italy.ORCID 0000-0001-5307-6103
University of Catania · IT

Funding

University of Catania PIACERI 2020-2022
6 · The paper itself

Abstract

Dopamine receptors (DRs) are generally considered as mediators of vasomotor functions. However, when used in pharmacological studies, dopamine and/or DR agonists may not discriminate among different DR subtypes and may even stimulate alpha1 and beta-adrenoceptors. Here, we tested the hypothesis that D2R and/or D3R may specifically induce vasoconstriction in isolated mouse aorta. Aorta, isolated from wild-type (WT) and D3R

Indexed as

AnimalsAortaIndolesMaleMiceMice, Inbred C57BLMice, KnockoutNitrilesPiperidinesReceptors, Dopamine D2Receptors, Dopamine D3RNA, MessengerTetrahydroisoquinolinesTetrahydronaphthalenesVasoconstriction3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole7-hydroxy-2-N,N-dipropylaminotetralinIndolesNitrilesPiperidinesReceptors, Dopamine D2Receptors, Dopamine D3RNA, MessengerSB 277011TetrahydroisoquinolinesTetrahydronaphthalenes7-OH-DPATdopamine receptorsL741,626mouse aortaSB-277011-Avasoconstriction

Identifiers

PMID33799860
PMCPMC8001456
OpenAlexW3134477031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.