Evidence map›Paper›PMID 33799812›Full record

ArticleInternational journal of molecular sciences2021

Dietary Micronutrient Management to Treat Mitochondrial Dysfunction in Diet-Induced Obese Mice.

Fabiano Cimmino, Angela Catapano, Giovanna Trinchese, Gina Cavaliere, Rosanna Culurciello, Chiara Fogliano, Eduardo Penna, Valeria Lucci, Marianna Crispino, Bice Avallone and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Fabiano CimminoDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Angela CatapanoDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Giovanna TrincheseDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0002-4096-6876
Gina CavaliereDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Rosanna CulurcielloDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Chiara FoglianoDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Eduardo PennaDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0003-0831-9748
Valeria LucciDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Marianna CrispinoDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0002-5797-8830
Bice AvalloneDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0002-5355-1557
Elio PizzoDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Maria Pina MollicaDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
University of Naples Federico II · ITInstitute for Experimental Endocrinology and Oncology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity and associated metabolic disturbances, which have been increasing worldwide in recent years, are the consequences of unhealthy diets and physical inactivity and are the main factors underlying non-communicable diseases (NCD). These diseases are now responsible for about three out of five deaths worldwide, and it has been shown that they depend on mitochondrial dysfunction, systemic inflammation and oxidative stress. It was also demonstrated that several nutritional components modulating these processes are able to influence metabolic homeostasis and, consequently, to prevent or delay the onset of NCD. An interesting combination of nutraceutical substances, named DMG-gold, has been shown to promote metabolic and physical wellness. The aim of this research was to investigate the metabolic, inflammatory and oxidative pathways modulated by DMG-gold in an animal model with diet-induced obesity. Our data indicate that DMG-gold decreases the metabolic efficiency and inflammatory state and acts as an antioxidant and detoxifying agent, modulating mitochondrial functions. Therefore, DMG-gold is a promising candidate in the prevention/treatment of NCD.

Indexed as

DietDietary SupplementsAnimalsAntioxidantsDiet, High-FatDisease Models, AnimalHumansInflammationMaleMiceMice, Inbred C57BLMicronutrientsMitochondriaObesityOxidation-ReductionOxidative StressAntioxidantsMicronutrientsdimethylglycineinflammationmicronutrientsmitochondrianon-communicable diseasesobesityoxidative stressvitamin B

Identifiers

PMID33799812
PMCPMC8000238
OpenAlexW3135375678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.