Evidence map›Paper›PMID 33799713›Full record

ArticleMolecules (Basel, Switzerland)2021

Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic Applications.

Sumedh Kamble, Peter Valtchev, Aiken Dao, Théophile Pelras, Michael J Rogers, Paul B Savage, Fariba Dehghani, Aaron Schindeler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sumedh KambleBioengineering and Molecular Medicine Laboratory, Kids Research at The Children's Hospital at Westmead, Westmead, NSW 2145, Australia.
Peter ValtchevSchool of Chemical and Biomolecular Engineering, University of Sydney, Camperdown, NSW 2008, Australia.ORCID 0000-0002-2622-5721
Aiken DaoBioengineering and Molecular Medicine Laboratory, Kids Research at The Children's Hospital at Westmead, Westmead, NSW 2145, Australia.ORCID 0000-0002-0631-2975
Théophile PelrasKey Centre for Polymers and Colloids, School of Chemistry and Sydney Nano, University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0002-2426-5009
Michael J RogersGarvan Institute of Medical Research, St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, NSW 2010, Australia.
Paul B SavageDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84601, USA.
Fariba DehghaniSchool of Chemical and Biomolecular Engineering, University of Sydney, Camperdown, NSW 2008, Australia.
Aaron SchindelerBioengineering and Molecular Medicine Laboratory, Kids Research at The Children's Hospital at Westmead, Westmead, NSW 2145, Australia.
The University of Sydney · AUBrigham Young University · USGarvan Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteomyelitis and orthopedic infections are major clinical problems, limited by a lack of antibiotics specialized for such applications. In this paper, we describe the design and synthesis of a novel bone-binding antibiotic (BBA-1) and its subsequent structural and functional characterization. The synthesis of BBA-1 was the result of a two-step chemical conjugation of cationic selective antimicrobial-90 (CSA-90) and the bisphosphonate alendronate (ALN) via a heterobifunctional linker. This was analytically confirmed by HPLC, FT-IR, MS and NMR spectroscopy. BBA-1 showed rapid binding and high affinity to bone mineral in an in vitro hydroxyapatite binding assay. Kirby-Baur assays confirmed that BBA-1 shows a potent antibacterial activity against

Indexed as

3T3 CellsAlendronateAnimalsAnti-Bacterial AgentsAnti-Infective AgentsBone and BonesCalcification, PhysiologicCell DifferentiationCells, CulturedDiphosphonatesMethicillin-Resistant Staphylococcus aureusMiceOsteoblastsOsteogenesisOsteomyelitisPregnanesAlendronateAnti-Bacterial AgentsAnti-Infective AgentsCSA-90DiphosphonatesPregnanesPropylaminesalendronateantimicrobialBBA-1bone infectionCSA-90osteomyelitis

Identifiers

PMID33799713
PMCPMC7999004
OpenAlexW3135762908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.