Evidence map›Paper›PMID 33799709›Full record

ArticleCancers2021

Blood-Based Detection of BRAF V600E in Gliomas and Brain Tumor Metastasis.

Keiko M Kang, Koushik Muralidharan, Anudeep Yekula, Julia L Small, Zachary S Rosh, Pamela S Jones, Bob S Carter, Leonora Balaj

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Network approach in liquidomics landscape.Journal of experimental & clinical cancer research : CR · 2023
    Review
  6. Cell-free DNA-based liquid biopsies in neurology.Brain : a journal of neurology · 2023
    Review
  7. Article
  8. Article
  9. Liquid biopsy: early and accurate diagnosis of brain tumor.Journal of cancer research and clinical oncology · 2022
    Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Keiko M KangDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Koushik MuralidharanDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Anudeep YekulaDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0713-0292
Julia L SmallDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7135-6299
Zachary S RoshDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Pamela S JonesDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Bob S CarterDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Leonora BalajDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0931-9715
Harvard University · US

Funding

The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAREST, ALAIN · 1996 to 2021
$30.9M
Liquid Biopsy for treatment stratification of IDH1.R132H and EGFRvIII mutant gliomasU01CA230697 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CARTER, BOB S, SKOG, JOHAN · 2018 to 2022
$4.0M
Imaging and Liquid Biopsy for Glioma Diagnosis and Treatment MonitoringR01CA239078 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BALAJ, LEONORA, LEE, HAKHO · 2020 to 2024
$3.1M
Standardized Molecular Analyses of Glioma EVsR01CA237500 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CARTER, BOB S, LEE, HAKHO · 2020 to 2024
$3.0M
Division of Cancer Prevention, National Cancer Institute CA069246Division of Cancer Prevention, National Cancer Institute CA230697Division of Cancer Prevention, National Cancer Institute CA237500Division of Cancer Prevention, National Cancer Institute CA239078NCI NIH HHS P01 CA069246NCI NIH HHS R01 CA237500NCI NIH HHS R01 CA239078NCI NIH HHS U01 CA230697
6 · The paper itself

Abstract

Liquid biopsy provides a minimally invasive platform for the detection of tumor-derived information, including hotspot mutations, such as BRAF V600E. In this study, we provide evidence of the technical development of a ddPCR assay for the detection of BRAF V600E mutations in the plasma of patients with glioma or brain metastasis. In a small patient cohort (

Indexed as

brain tumorbrain tumor metastasiscfDNA (cell free DNA)extracellular vesiclesgliomaliquid biopsymelanoma

Identifiers

PMID33799709
PMCPMC7998685
OpenAlexW3134005903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.