ReviewDentistry journal2021
Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review.
Review in Dentistry journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Oral manifestations of COVID-19 and its management in pediatric patients: A systematic review and practical guideline.Clinical and experimental dental research · 2023Pooled it
- Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- A Review of Prolonged Post-COVID-19 Symptoms and Their Implications on Dental Management.International journal of environmental research and public health · 2021Pooled it
- Homoeriodictyol, targeting the bitter taste receptor TAS2R14, lowers the secretion of pro-inflammatory chemokines upon treatment with SARS-CoV-2 peptide pools in human peripheral blood mononuclear cells.Frontiers in immunology · 2026Article
- Impact of Symptomatic COVID-19 on the Oral Health of Pediatric Patients in Tbilisi City.Children (Basel, Switzerland) · 2025Article
- Characteristics of Oral Adverse Effects following COVID-19 Vaccination and Similarities with Oral Symptoms in COVID-19 Patients: Taste and Saliva Secretory Disorders.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025Review
- Xerostomia in survivors of severe COVID-19: findings from a Latin American cohort.Frontiers in oral health · 2025Article
- Oral manifestations of COVID-19 vaccinated individuals, post-infection, and different variants: a Brazilian population study.Brazilian oral research · 2025Article
- SARS-CoV-2 infection of salivary glands compromises the production of a secreted antifungal peptide with potential implications for development of oral candidiasis.PLoS pathogens · 2024Article
- Frequency of Oral Lesions, Olfactory, and Gustatory Disorders and Xerostomia in Patients with COVID-19.Dentistry journal · 2024Article
- Long COVID, the Brain, Nerves, and Cognitive Function.Neurology international · 2023Review
- Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders.Dentistry journal · 2023Review
- Assessment of Salivary pH, Buffer Capacity, and Flow in COVID-19-Infected and Vaccinated Dental Patients.Cureus · 2023Article
- Loss of Sour Taste Is the Striking Feature among Four Basic Taste Qualities in Tunisian COVID-19 Patients.Journal of clinical medicine · 2023Article
- Oral Changes in Hospitalized COVID-19 Patients: A Cross-Sectional Multicentric Study.International journal of dentistry · 2023Article
- Progress in salivary glands: Endocrine glands with immune functions.Frontiers in endocrinology · 2023Review
- COVID-19 Oral Sequelae: Persistent Gustatory and Saliva Secretory Dysfunctions after Recovery from COVID-19.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2023Review
- A reflection on COVID-19 and oral mucosal lesion: a systematic review.Frontiers in oral health · 2023Review
- A multi-country study on the impact of sex and age on oral features of COVID-19 infection in adolescents and young adults.BMC oral health · 2022Article
- Oral lesions and saliva alterations of COVID-19 patients in an intensive care unit: A retrospective study.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Since the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, management of coronavirus disease 2019 (COVID-19) has been challenging for healthcare providers. The oral cavity is referred to as a target of SARS-CoV-2. The aim of this study was to review oral symptoms specific to COVID-19 patients from the point of view of symptom prevalence and pathogenesis and to speculate the pathogenic mechanisms underlying them. Scientific articles were retrieved by searching PubMed/MEDLINE, Google Scholar, medRxiv, and bioRxiv from 3 February 2020 to 31 December 2020, and they were reviewed by title, abstract, and text for relevance. The literature search indicated that COVID-19 patients frequently present with gustatory dysfunction, xerostomia, and oral mucosal lesions, while their prevalence is likely to vary by country, age, gender, and disease severity. Gustatory dysfunction and xerostomia appear at an early stage of SARS-CoV-2 infection and last relatively long. One of possible pathogenic mechanisms of both symptoms is attributed to the expression of viral cellular entry-relevant receptors in taste cells and salivary glands. Dental professionals who can first become aware of oral symptoms associated with COVID-19 will play a more active role in and make a greater contribution to diagnosis and prevention of COVID-19.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.