ArticleBrain sciences2021
Disrupted Pallido-Thalamo-Cortical Functional Connectivity in Chronic Disorders of Consciousness.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Disrupted hierarchical organization in disorders of consciousness revealed by fluctuation-dissipation deviations.bioRxiv : the preprint server for biology · 2025Article
- An MRI Deep Brain Adult Template With An Advanced Atlas-Based Tool For Diffusion Tensor Imaging Analysis.Scientific data · 2024Article
- Changes in Spatiotemporal Dynamics of Default Network Oscillations between 19 and 29 Years of Age.Brain sciences · 2024Article
- Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues.Brain sciences · 2021Article
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6 authors.
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Abstract
Chronic disorders of consciousness (DOC) encompass unresponsive wakefulness syndrome and minimally conscious state. Their anatomo-functional correlates are not clearly defined yet, although impairments of functional cortical networks have been reported, as well as the implication of the thalamus and deep brain structures. However, the pallidal functional connectivity with the thalamus and the cortical networks has not been studied so far. Using resting-state functional MRI, we conducted a functional connectivity study between the pallidum, the thalamus and the cortical networks in 13 patients with chronic DOC and 19 healthy subjects. We observed in chronic DOC patients that the thalami were no longer connected to the cortical networks, nor to the pallidums. Concerning the functional connectivity of pallidums, we reported an abolition of the negative correlation with the default mode network, and of the positive correlation with the salience network. The disrupted functional connectivity observed in chronic DOC patients between subcortical structures and cortical networks could be related to the mesocircuit model. A better understanding of the DOC underlying physiopathology could provide food for thought for future therapeutic proposals.
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