Evidence map›Paper›PMID 33799578›Full record

ArticleBiomedicines2021

Cerebroprotective Effects of 2-Ethyl-6-methyl-3-hydroxypyridine-2,6-dichlorophenyl(amino)phenylethanoic Acid in the Treatment of Purulent Meningitis.

Alina Agarkova, Mikhail Pokrovskii, Pavel Kolesnichenko, Vladimir Gureev, Oleg Gudyrev, Anna Peresypkina, Vladislav Soldatov, Arkadii Nesterov, Tatyana Denisyuk, Mikhail Korokin

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In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alina AgarkovaDepartment of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, 308015 Belgorod, Russia.ORCID 0000-0002-2538-2696
Mikhail PokrovskiiDepartment of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, 308015 Belgorod, Russia.
Pavel KolesnichenkoDepartment of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, 308015 Belgorod, Russia.
Vladimir GureevDepartment of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, 308015 Belgorod, Russia.
Oleg GudyrevDepartment of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, 308015 Belgorod, Russia.
Anna PeresypkinaDepartment of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, 308015 Belgorod, Russia.ORCID 0000-0003-2829-9860
Vladislav SoldatovDepartment of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, 308015 Belgorod, Russia.
Arkadii NesterovDepartment of Pathology, Belgorod State National Research University, 308015 Belgorod, Russia.ORCID 0000-0003-3822-4213
Tatyana DenisyukDepartment of Pharmacology, Kursk State Medical University, 305000 Kursk, Russia.
Mikhail KorokinDepartment of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, 308015 Belgorod, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purulent meningitis (PM) is a severe disease, characterized by high mortality and a formation of a residual neurological deficit. Loss of treatment of PM leads to the lethal outcome in 100% of cases. In addition, death and the development of residual neurological complications are possible despite adequate therapy. The aim of the study was to evaluate the cerebroprotective effects of a new pharmacological compound 2-ethyl-6-methyl-3-hydroxypyridine-2,6-dichlorophenyl(amino)phenylethanoic acid (EMHDPA) on the bacterial purulent meningitis in a model of experimental pneumococcal meningitis. Meningitis was simulated by intrathecal injection of the suspension containing

Indexed as

bacterial meningitiscerebroprotectionpneumococcal meningitistreatment of bacterial meningitis

Identifiers

PMID33799578
PMCPMC7998598

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.