Evidence map›Paper›PMID 33799523›Full record

ArticleMolecules (Basel, Switzerland)2021

Determination of Intact Parabens in the Human Plasma of Cancer and Non-Cancer Patients Using a Validated Fabric Phase Sorptive Extraction Reversed-Phase Liquid Chromatography Method with UV Detection.

Anthi Parla, Eirini Zormpa, Nikolaos Paloumpis, Abuzar Kabir, Kenneth G Furton, Željka Roje, Victoria Samanidou, Ivana Vinković Vrček, Irene Panderi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 20 citations in OpenAlex.

  1. Oestrogenic and androgenic activity of oxybenzone and methylparabenArhiv za higijenu rada i toksikologiju · 2025
    Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Anthi ParlaLaboratory of Pharmaceutical Analysis, Division of Pharmaceutical Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece.
Eirini ZormpaLaboratory of Pharmaceutical Analysis, Division of Pharmaceutical Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece.
Nikolaos PaloumpisLaboratory of Pharmaceutical Analysis, Division of Pharmaceutical Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece.ORCID 0000-0001-5436-7148
Abuzar KabirDepartment of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA.ORCID 0000-0002-3740-8857
Kenneth G FurtonDepartment of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA.ORCID 0000-0003-2941-2597
Željka RojeDepartment for Plastic, Reconstructive and Aesthetic Surgery, University Hospital Dubrava, 10 000 Zagreb, Croatia.ORCID 0000-0003-3962-4454
Victoria SamanidouLaboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-8493-1106
Ivana Vinković VrčekInstitute for Medical Research and Occupational Health, Ksaverska cesta 2, 10 000 Zagreb, Croatia.ORCID 0000-0003-1382-5581
Irene PanderiLaboratory of Pharmaceutical Analysis, Division of Pharmaceutical Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece.ORCID 0000-0003-3190-0127
National and Kapodistrian University of Athens · GRFlorida International University · USAristotle University of Thessaloniki · GRInstitute for Medical Research and Occupational Health · HRUniversity Hospital Dubrava · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parabens have been widely employed as preservatives since the 1920s for extending the shelf life of foodstuffs, medicines, and daily care products. Given the fact that there are some legitimate concerns related to their potential multiple endocrine-disrupting properties, the development of novel bioanalytical methods for their biomonitoring is crucial. In this study, a fabric phase sorptive extraction reversed-phase liquid chromatography method coupled with UV detection (FPSE-HPLC-UV) was developed and validated for the quantitation of seven parabens in human plasma samples. Chromatographic separation of the seven parabens and

Indexed as

Chromatography, High Pressure LiquidChromatography, Reverse-PhaseEndocrine DisruptorsFemaleHumansLimit of DetectionParabensPlasmaPreservatives, PharmaceuticalSolid Phase ExtractionTextiles4-hydroxybenzoic acidEndocrine DisruptorsisobutylparabenmethylparabenParabensPreservatives, Pharmaceuticalbioanalysisfabric phase sorptive extraction (FPSE)human plasmaparabensp-hydroxybenzoic acid esters

Identifiers

PMID33799523
PMCPMC8002076
OpenAlexW3134768297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.