Evidence map›Paper›PMID 33799461›Full record

ArticleInternational journal of molecular sciences2021

Proteomics Profiling of Neuron-Derived Small Extracellular Vesicles from Human Plasma: Enabling Single-Subject Analysis.

Federica Anastasi, Silvia Maria Masciandaro, Renata Del Carratore, Maria Teresa Dell'Anno, Giovanni Signore, Alessandra Falleni, Liam A McDonnell, Paolo Bongioanni

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Federica AnastasiNational Enterprise for NanoScience and NanoTechnology, Scuola Normale Superiore, 56127 Pisa, Italy.ORCID 0000-0002-9304-5421
Silvia Maria MasciandaroNational Research Council, Institute of Clinical Physiology Research, 56124 Pisa, Italy.ORCID 0000-0001-7052-2320
Renata Del CarratoreNational Research Council, Institute of Clinical Physiology Research, 56124 Pisa, Italy.
Maria Teresa Dell'AnnoFondazione Pisana per la Scienza ONLUS, 56017 San Giuliano Terme, Italy.ORCID 0000-0003-1825-671X
Giovanni SignoreFondazione Pisana per la Scienza ONLUS, 56017 San Giuliano Terme, Italy.ORCID 0000-0002-0067-2240
Alessandra FalleniUnit of Applied Biology and Genetics, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Liam A McDonnellFondazione Pisana per la Scienza ONLUS, 56017 San Giuliano Terme, Italy.
Paolo BongioanniSevere Acquired Brain Injuries Dpt Section, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.
Fondazione Pisa · ITIstituto di Fisiologia Clinica · ITAssociazione Italiana Vulvodinia Onlus · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small extracellular vesicles have been intensively studied as a source of biomarkers in neurodegenerative disorders. The possibility to isolate neuron-derived small extracellular vesicles (NDsEV) from blood represents a potential window into brain pathological processes. To date, the absence of sensitive NDsEV isolation and full proteome characterization methods has meant their protein content has been underexplored, particularly for individual patients. Here, we report a rapid method based on an immunoplate covalently coated with mouse monoclonal anti-

Indexed as

BiomarkersChromatography, LiquidExosomesExtracellular VesiclesHumansNeuronsParkinson DiseaseProteomeProteomicsTandem Mass SpectrometryBiomarkersProteomecentral nervous systemexosomesL1CAMmiR-155NES cellsneuron-derived vesiclesParkinson’s diseaseplasmaproteomicssmall extracellular vesicles

Identifiers

PMID33799461
PMCPMC7999506
OpenAlexW3136960043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.