Evidence map›Paper›PMID 33799420›Full record

ArticleSensors (Basel, Switzerland)2021

Detecting Parkinson's Disease from Wrist-Worn Accelerometry in the U.K. Biobank.

James R Williamson, Brian Telfer, Riley Mullany, Karl E Friedl

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  16. Gait Monitoring and Analysis: A Mathematical Approach.Sensors (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

James R WilliamsonLincoln Laboratory, Massachusetts Institute of Technology, Lexington, MA 02421, USA.
Brian TelferLincoln Laboratory, Massachusetts Institute of Technology, Lexington, MA 02421, USA.
Riley MullanyLincoln Laboratory, Massachusetts Institute of Technology, Lexington, MA 02421, USA.
Karl E FriedlU.S. Army Research Institute of Environmental Medicine, Natick, MA 01760, USA.ORCID 0000-0002-3134-8427

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a chronic movement disorder that produces a variety of characteristic movement abnormalities. The ubiquity of wrist-worn accelerometry suggests a possible sensor modality for early detection of PD symptoms and subsequent tracking of PD symptom severity. As an initial proof of concept for this technological approach, we analyzed the U.K. Biobank data set, consisting of one week of wrist-worn accelerometry from a population with a PD primary diagnosis and an age-matched healthy control population. Measures of movement dispersion were extracted from automatically segmented gait data, and measures of movement dimensionality were extracted from automatically segmented low-movement data. Using machine learning classifiers applied to one week of data, PD was detected with an area under the curve (AUC) of 0.69 on gait data, AUC = 0.84 on low-movement data, and AUC = 0.85 on a fusion of both activities. It was also found that classification accuracy steadily improved across the one-week data collection, suggesting that higher accuracy could be achievable from a longer data collection. These results suggest the viability of using a low-cost and easy-to-use activity sensor for detecting movement abnormalities due to PD and motivate further research on early PD detection and tracking of PD symptom severity.

Indexed as

Wearable Electronic DevicesAccelerometryAdultAgedBiological Specimen BanksGaitHumansMachine LearningMiddle AgedMonitoring, PhysiologicParkinson DiseaseTremorWristin-the-wildParkinson’s diseaseU.K. Biobankwearable accelerometers

Identifiers

PMID33799420
PMCPMC7999802

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.