SynthesisNutrients2021
Amino Acid Formula Containing Synbiotics in Infants with Cow's Milk Protein Allergy: A Systematic Review and Meta-Analysis.
Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
- Individualized Nutritional and Microbiome-Oriented Management of Food Allergy-Associated Atopic Dermatitis in Children: A Prospective Real-World Observational Cohort Study.Foods (Basel, Switzerland) · 2026Article
- Cow's Milk Protein Allergy, a Systematic Review of Clinical Characteristics, Diagnosis, Management, and Economic Impact.Diseases (Basel, Switzerland) · 2026Review
- Amino acid-based formula with synbiotics for cow's milk protein allergy: a real-world study of symptom evolution and quality-of-life outcomes.Frontiers in pediatrics · 2026Article
- Wheat-Dependent Exercise-Induced Anaphylaxis Patients on a Wheat-Free Diet Exhibit a Gut Microbiota Composition More Similar to Healthy Individuals.Journal of asthma and allergy · 2026Article
- Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health-A Narrative Review.Molecular nutrition & food research · 2026Review
- Model-based cost-effectiveness analysis of the diagnosis and treatment of cow's milk protein allergy with amino acid-based formula compared to extensively hydrolyzed formula in Argentina.Frontiers in pediatrics · 2025Article
- Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid-based formula during early life: results of a randomized controlled trial (PRESTO study).Frontiers in allergy · 2025Article
- Regional differences in diagnosis and management of cow's milk allergy.Clinical and experimental pediatrics · 2024Article
- A synbiotic of Anaerostipes caccae and lactulose prevents and treats food allergy in mice.Cell host & microbe · 2024Article
- Cow's Milk Protein Allergy.Indian journal of pediatrics · 2024Review
- Symptoms and management of cow's milk allergy: perception and evidence.Frontiers in allergy · 2024Article
- Informatics for your Gut: at the Interface of Nutrition, the Microbiome, and Technology.Yearbook of medical informatics · 2023Review
- Pre-, pro-, syn-, and Postbiotics in Infant Formulas: What Are the Immune Benefits for Infants?Nutrients · 2023Review
- Short-term symptom improvement in infants with suspected cow's milk protein allergy using amino acid formula: a prospective cohort analysis.Frontiers in nutrition · 2023Article
- The use of amino acid formulas in pediatric patients with allergy to cow's milk proteins: Recommendations from a group of experts.Frontiers in pediatrics · 2023Review
- Microbiome Therapeutics for Food Allergy.Nutrients · 2022Review
- The health economic impact of cow's milk allergy in childhood: A retrospective cohort study.Clinical and translational allergy · 2022Article
- Synbiotic containing extensively hydrolyzed formula improves gastrointestinal and atopic symptom severity, growth, caregiver quality of life, and hospital-related healthcare use in infants with cow's milk allergy.Immunity, inflammation and disease · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cow's milk protein allergy (CMPA) is associated with dysbiosis of the infant gut microbiome, with allergic and immune development implications. Studies show benefits of combining synbiotics with hypoallergenic formulae, although evidence has never been systematically examined. This review identified seven publications of four randomised controlled trials comparing an amino acid formula (AAF) with an AAF containing synbiotics (AAF-Syn) in infants with CMPA (mean age 8.6 months; 68% male, mean intervention 27.3 weeks,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.