Evidence map›Paper›PMID 33799348›Full record

ArticleMolecules (Basel, Switzerland)2021

The Effect of Hispidulin, a Flavonoid from

Yiqun Dai, Xiaolong Sun, Bohan Li, Hui Ma, Pingping Wu, Yingping Zhang, Meilin Zhu, Hong-Mei Li, Minjian Qin, Cheng-Zhu Wu

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Phytochemical Characterization and Anticancer Activity ofInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yiqun DaiSchool of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, China.
Xiaolong SunSchool of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, China.
Bohan LiSchool of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, China.
Hui MaSchool of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, China.
Pingping WuSchool of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, China.
Yingping ZhangSchool of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, China.
Meilin ZhuSchool of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, China.
Hong-Mei LiSchool of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, China.
Minjian QinDepartment of Resources Science of Traditional Chinese Medicines, School of Traditional Chinese Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.ORCID 0000-0001-8539-7649
Cheng-Zhu WuSchool of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, China.
Bengbu Medical College · CNChina Pharmaceutical University · CN

Funding

Natural Science Research Project of Anhui Educational Committee KJ2019A0335, KJ2018A0232Science Research Project of Bengbu Medical College BYKY1805ZDUndergraduate Innovation and Entrepreneurship Training Program of Anhui Educational Committee S202010367124
6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is a common malignant head and neck tumor. Drug resistance and distant metastasis are the predominant cause of treatment failure in NPC patients. Hispidulin is a flavonoid extracted from the bioassay-guided separation of the EtOH extract of

Indexed as

AnimalsApoptosisCell Line, TumorCell MovementCell ProliferationFlavonesFlavonoidsHumansMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMice, Inbred BALB CMice, NudeNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeoplasm InvasivenessFlavonesFlavonoidshispidulinMatrix Metalloproteinase 2Matrix Metalloproteinase 9Proto-Oncogene Proteins c-bcl-2Tissue Inhibitor of Metalloproteinase-1apoptosishispidulininvasionmigrationnasopharyngeal carcinoma

Identifiers

PMID33799348
PMCPMC8001992
OpenAlexW3136390446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.